GTP Cyclohydrolase 1 (GCH1) ELISA试剂盒

GCH1 encodes a member of the GTP cyclohydrolase family. 再加上,我们可以发GTP Cyclohydrolase 1 抗体 (90)GTP Cyclohydrolase 1 蛋白 (12)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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5.8 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
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适于 GTP Cyclohydrolase 1 相互作用对的更多 ELISA 试剂盒

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. This study indicates that mutations in GCH1 are rare in late-onset Parkinson disease.

  2. This study shown GCH1 genetic variants for Parkinson's disease are associated with the risk of incident Parkinson's disease in the general population and with impairment in daily functioning in individuals without clinical parkinsonism.

  3. GCH1 variants affect early PD risk through altered dopamine uptake, and aging alters how genetic factors contribute to disease development.

  4. This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.

  5. Deletion of GCH1 likely contributes to dopa-responsive dystonia.

  6. High GCH1 expression is associated with esophageal squamous cell carcinoma.

  7. Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 gene as well as in the PARK2 (显示 PARK2 ELISA试剂盒) gene.

  8. This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.

  9. No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.

  10. GTPCH/Ang-1 (显示 ANGPT1 ELISA试剂盒) interaction in stromal fibroblasts and activation of Tie2 (显示 TEK ELISA试剂盒) on breast tumor cells could play an important role in supporting breast cancer growth. GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  2. gene expression analysis after iNOS (显示 NOS2 ELISA试剂盒) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (显示 FLT3LG ELISA试剂盒))Tie2cre macrophages

  3. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  4. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  5. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (显示 FCGR1A ELISA试剂盒) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  6. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  7. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  8. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1) mouse, is reported.

  9. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  10. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

GTP Cyclohydrolase 1 (GCH1) 抗原简介

Antigen Summary

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with GCH1

  • GTP cyclohydrolase 1 (GCH1) 抗体
  • GTP cyclohydrolase 1 (Gch1) 抗体
  • GTP cyclohydrolase 1 (gch1) 抗体
  • GTP cyclohydrolase 1 (Weevi_1190) 抗体
  • GTP cyclohydrolase 1 (Halhy_0838) 抗体
  • GTP cyclohydrolase 1 (Sinme_1220) 抗体
  • GTP cyclohydrolase 1 (Sphch_1077) 抗体
  • GTP cyclohydrolase 1-like (LOC100136794) 抗体
  • DYT5 抗体
  • DYT5a 抗体
  • DYT14 抗体
  • Gch 抗体
  • gch1a 抗体
  • GTP-CH 抗体
  • GTP-CH-1 抗体
  • GTPCH 抗体
  • GTPCH1 抗体
  • HPABH4B 抗体
  • MGC89622 抗体
  • wu:fc16b10 抗体
  • zgc:195269 抗体

Protein level used designations for GCH1

GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I (form A; N-terminus)

2643 Homo sapiens
609393 Canis lupus familiaris
286815 Bos taurus
695675 Macaca mulatta
743728 Pan troglodytes
396146 Gallus gallus
14528 Mus musculus
29244 Rattus norvegicus
448485 Xenopus (Silurana) tropicalis
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100136794 Oncorhynchus mykiss
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
100735198 Cavia porcellus
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