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FMNL2 encodes a formin-related protein. 再加上，我们可以发FMNL2 试剂盒 (4) 和 FMNL2 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Monoclonal FMNL2 Primary Antibody for ELISA, WB - ABIN566725
Zhu, Liang, Ding: Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. in International journal of colorectal disease 2008
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Human Polyclonal FMNL2 Primary Antibody for ICC, IF - ABIN4312213
Gardberg, Talvinen, Kaipio, Iljin, Kampf, Uhlen, Carpén: Characterization of Diaphanous-related formin FMNL2 in human tissues. in BMC cell biology 2010
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FMNL1 (显示 FMNL1 抗体) and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
mDia1-FH2 has an effect on the conformation of actin filaments
FMNL2 knockout cells were characterized by impaired filopodia formation similar to depletion of the Rho GTPase (显示 RACGAP1 抗体) Cdc42 (显示 CDC42 抗体).
Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB (显示 NFkBP65 抗体) axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer.
Our data proved that RMRP (显示 NME1 抗体) acted as an oncogene (显示 RAB1A 抗体) LncRNA to promote the expression of KRAS, FMNL2 and SOX9 (显示 SOX9 抗体) by inhibiting miR (显示 MLXIP 抗体)-206 expression in lung cancer. These data suggested that RMRP (显示 NME1 抗体) might serve as a therapeutic target in lung adenocarcinoma
FMNL2 is likely to be generally required in melanoma cells for invasion.
miR (显示 MLXIP 抗体)-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC (显示 CALR 抗体)) by targeting FMNL2 and c-MET. Restoration of miR (显示 MLXIP 抗体)-206 expression may represent a promising therapeutic approach for targeting malignant CRC (显示 CALR 抗体).
Capping protein and FMNL2 functionally coregulate filament barbed-end assembly.
The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia.
These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness.
MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5.
Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2.
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
formin-like domain containing protein MAN
, formin-like protein 2
, protein Man
, formin homology 2 domain containing 2
, formin homology 2 domain-containing protein 2
, formin-like 2