This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq, Jul 2008].
Alvarez, Agaisse: "The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility." in: The Journal of cell biology, Vol. 202, Issue 7, pp. 1075-90, (2013) (PubMed).
Gardberg, Kaipio, Lehtinen, Mikkonen, Heuser, Talvinen, Iljin, Kampf, Uhlen, Grénman, Koivisto, Carpén: "FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion." in: PLoS ONE, Vol. 8, Issue 9, pp. e74923, (2013) (PubMed).