The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Kakimoto, Katoh, Negishi: "Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination." in: The Journal of biological chemistry, Vol. 281, Issue 39, pp. 29042-53, (2006) (PubMed).
Ho, Rohatgi, Lebensohn, Le Ma, Li, Gygi, Kirschner: "Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex." in: Cell, Vol. 118, Issue 2, pp. 203-16, (2004) (PubMed).
Aliases for FNBP1L 抗体
formin binding protein 1 like (FNBP1L) 抗体 formin binding protein 1-like (Fnbp1l) 抗体 formin binding protein 1-like (fnbp1l) 抗体 formin binding protein 1 like (fnbp1l) 抗体 formin binding protein 1 like L homeolog (fnbp1l.L) 抗体 formin binding protein 1 like S homeolog (fnbp1l.S) 抗体 2610318I01Rik 抗体 AW548221 抗体 C1orf39 抗体 fnbp1l 抗体 MGC132162 抗体 RGD1305386 抗体 Toca-1 抗体 toca-1 抗体 TOCA1 抗体 toca1 抗体 zgc:100923 抗体