Folylpolyglutamate Synthase 蛋白 (FPGS)

FPGS encodes the folylpolyglutamate synthetase enzyme. 再加上,我们可以发FPGS 抗体 (41)FPGS 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FPGS 2356 Q05932
大鼠 FPGS FPGS 687266  
FPGS 14287 P48760
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Showing 4 out of 5 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
大肠杆菌(E. Coli) 小鼠 非结合性 SDS-PAGE analysis of Mouse FPGS Protein. 100 μg Log in to see 11至18个工作日

FPGS 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
Mouse (Murine) ,

更多Folylpolyglutamate Synthase (FPGS)互动伙伴

Human Folylpolyglutamate Synthase (FPGS) interaction partners

  1. The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.

  2. Low expression level of FPGS is associated with neuroendocrine lung tumors.

  3. Our results revealed a significant difference of overall survival between patients with AA genotype and GA + GG genotype (P<0.05). Our study demonstrated a correlation of the polymorphism of FPGS rs1544105 with MTX treatment efficacy, as well as with overall survival, suggesting it could be used as an effective approach in the prediction of MTX treatment efficacy

  4. These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors.

  5. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS rs7856096, and STX1B rs4889606.

  6. data suggest that FPGS modulation affects global and promoter CpG DNA methylation and expression of several genes involved in important biological pathways

  7. the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum

  8. FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.

  9. Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk.

  10. study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma

  11. antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12.

  12. Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR, FPGS and TYMS.

  13. mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane

  14. Polymorphism of FPGS rs1544105 G>A is associated with response to therapy in acute lymphoblastic leukemia.

  15. An interaction term, between FPGS rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to methotrexate toxicity in rheumatoid arthritis.

  16. High Folylpoly-glutamate synthetase expression is associated with response to therapy in non-small-cell lung cancer.

  17. A novel missense mutation 502/490 T>C (L151/101P) in exon 5 of FPGS gene is firstly found in Chinese Han children, and the cytosolic and mitochondrial variants display allelic frequencies of 0.70 % and 0.47 % respectively.

  18. The mbr enhanced the expression of FPGS significantly and increased sensitivity of Jurkat cells to MTX efficiently.

  19. This is one of the first studies to assess FPGS and GGH genetic variants in relation to plasma homocysteine.

  20. The expression of mFPGS was different in A549 cells exposed to different methotrexate enantiomers.

Mouse (Murine) Folylpolyglutamate Synthase (FPGS) interaction partners

  1. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.

  2. These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.



This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.

Gene names and symbols associated with FPGS

  • folylpolyglutamate synthase (fpgs)
  • folylpolyglutamate synthase (fpgS)
  • folylpolyglutamate synthase (FPGS)
  • folylpolyglutamate synthase (SCO2614)
  • folylpolyglutamate synthase (fgs)
  • folylpolyglutamate synthase (folC)
  • dihydrofolate synthase (folC)
  • folylpolyglutamate synthase, mitochondrial (CpipJ_CPIJ008043)
  • folylpolyglutamate synthase (Fpgs)
  • folylpolyglutamyl synthetase (Fpgs)
  • AA408187 蛋白
  • BA4689 蛋白
  • fpgS 蛋白
  • SCC88.25c 蛋白
  • wu:fk49h03 蛋白
  • wu:fk51d09 蛋白
  • zgc:63807 蛋白

Protein level used designations for FPGS

fk51d09 , folylpolyglutamate synthase, mitochondrial , folylpolyglutamate synthase , folylpoly-gamma-glutamate synthetase , tetrahydrofolate synthase , tetrahydrofolylpolyglutamate synthase , Folylpoly-gamma-glutamate synthetase , Tetrahydrofolate synthase , Tetrahydrofolylpolyglutamate synthase , folylpoly-gammaglutamate synthetase

406746 Danio rerio
1211280 Streptomyces avermitilis MA-4680
699587 Macaca mulatta
1098048 Streptomyces coelicolor A3(2)
609176 Canis lupus familiaris
1064577 Tropheryma whipplei TW08/27
1083723 Bacillus anthracis str. Ames
1208787 Coxiella burnetii RSA 493
2798635 Listeria monocytogenes serotype 4b str. F2365
3233504 Ehrlichia ruminantium str. Welgevonden
6040770 Culex quinquefasciatus
2356 Homo sapiens
505809 Bos taurus
687266 Rattus norvegicus
14287 Mus musculus
100689022 Cricetulus griseus
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