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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. 再加上，我们可以发FTO 试剂盒 (12) 和 FTO 蛋白 (10)和数多这个蛋白质的别的产品。
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Human Polyclonal FTO Primary Antibody for WB - ABIN258809
Walters, Mercaldo, Gillon, Yip, Neve, Boyce, Frankland, Josselyn: The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017
Human Polyclonal FTO Primary Antibody for ELISA, WB - ABIN316349
Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ... in Science (New York, N.Y.) 2007
Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage.
FTO variant is not associated with osteoarthritis in the Chinese Han population.
This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
FTO gene polymorphisms are associated with variability of HDL (显示 HSD11B1 抗体)-cholesterol concentrations which may lead to increased CVD risk in patients with acromegaly who are risk-allele carriers.
We observed no evidence for associations of rs1421085 in FTO with FatOx and RQ. This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.
This study reports interactions between the FTO variant and each of: frequency of alcohol consumption; deviations from mean sleep duration; overall diet, including added salt; and physical activity.
FTO rs9939609 Polymorphism is associated with Obesity.
Study showed that a haplotype in the first intron of the FTO gene had a strong association with obesity indices among Iranian adolescent males. None of the students with GGC (显示 GGCT 抗体) genotypes were underweight, while most of the students with AAT (显示 SERPINA1A 抗体) had high body mass.
The rs9939609 polymorphism in the FTO gene may be a genetic risk factor for malignant pleural mesothelioma.
FTO was highly expressed in motor neurons and is associated with with sporadic amyotrophic lateral sclerosis in Greek patients.
Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.
FTO demethylase (显示 MBD2 抗体) activity is essential for normal bone development and mineralization, a previously unreported FTO function.
FTO is critically involved in insulin (显示 INS 抗体) defects-related Alzheimer's disease.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (显示 HNRNPK 抗体) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (显示 HNRNPK 抗体) in FTO-associated transformations.
Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.
The involvement of mTOR (显示 FRAP1 抗体)-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (显示 RPGRIP1L 抗体), and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (显示 CSN2 抗体) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso