Elastase, Neutrophil Expressed 蛋白 (ELANE)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. 再加上,我们可以发Elastase, Neutrophil Expressed 抗体 (178)Elastase, Neutrophil Expressed 试剂盒 (106)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
大鼠 ELANE ELANE 299606  
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Showing 10 out of 15 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Human 非结合性 10 μg Log in to see 6至7个工作日
大肠杆菌(E. Coli) His tag,GST tag 100 μg Log in to see 15至18个工作日
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
Human 非结合性   200 μg Log in to see 6至7个工作日
Human 非结合性   0.1 mg Log in to see 2至3个工作日
人细胞 非结合性   25 μg Log in to see 11至12个工作日
大肠杆菌(E. Coli) 非结合性   100 μg Log in to see 11至18个工作日
非结合性   100 μg Log in to see 5至6个工作日

ELANE 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, ,
Mouse (Murine)

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Human Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.

  2. Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.

  3. The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (显示 EIF2AK3 蛋白) and CHOP (显示 DDIT3 蛋白) is reported.

  4. results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (显示 ELN 蛋白) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy

  5. Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.

  6. Data suggest that neuropilin-1 (NRP1 (显示 NRP1 蛋白)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (显示 TMEM37 蛋白) (a peptide fragment of NE) in breast cancer cells.

  7. This study proposes that acquisition of CSF3R (显示 CSF3R 蛋白) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (显示 SRI 蛋白) patients.

  8. Faecal biomarkers lactoferrin (显示 LTF 蛋白), calprotectin (显示 S100A8 蛋白), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

  9. In conclusion, site-specific CBG (显示 SERPINA6 蛋白) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (显示 C6orf108 蛋白) proteolysis by endogenous and exogenous elastases.

  10. Although circulating nucleosomes and elastase - alpha 1-antitrypsin (显示 SERPINA1 蛋白) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (显示 SLC44A2 蛋白) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (显示 CEBPA 蛋白)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (显示 CEBPA 蛋白) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (显示 F2 蛋白) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (显示 APOE 蛋白) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N (显示 SERPINA3N 蛋白) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

蛋白简介Elastase, Neutrophil Expressed (ELANE)


Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene names and symbols associated with ELANE

  • elastase, neutrophil expressed (ELANE)
  • elastase, neutrophil expressed (Elane)
  • proteinase 3 (prtn3)
  • ela2 蛋白
  • ELANE 蛋白
  • F430011M15Rik 蛋白
  • GE 蛋白
  • HLE 蛋白
  • HNE 蛋白
  • NE 蛋白
  • PMN-E 蛋白
  • SCN1 蛋白

Protein level used designations for ELANE

PMN elastase , bone marrow serine protease , elastase 2, neutrophil , elastase-2 , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , neutrophil elastase , polymorphonuclear elastase , serine protease , elastase, neutrophil expressed , LOW QUALITY PROTEIN: neutrophil elastase

1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100126050 Bos taurus
100301482 Felis catus
100724414 Cavia porcellus
100522182 Sus scrofa
102173292 Capra hircus
101110841 Ovis aries musimon
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