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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. 再加上，我们可以发Elastase, Neutrophil Expressed 抗体 (178) 和 Elastase, Neutrophil Expressed 试剂盒 (106)和数多这个蛋白质的别的产品。
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Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.
Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.
The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (显示 EIF2AK3 蛋白) and CHOP (显示 DDIT3 蛋白) is reported.
results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (显示 ELN 蛋白) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy
Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.
Data suggest that neuropilin-1 (NRP1 (显示 NRP1 蛋白)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (显示 TMEM37 蛋白) (a peptide fragment of NE) in breast cancer cells.
This study proposes that acquisition of CSF3R (显示 CSF3R 蛋白) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (显示 SRI 蛋白) patients.
Faecal biomarkers lactoferrin (显示 LTF 蛋白), calprotectin (显示 S100A8 蛋白), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.
In conclusion, site-specific CBG (显示 SERPINA6 蛋白) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (显示 C6orf108 蛋白) proteolysis by endogenous and exogenous elastases.
Although circulating nucleosomes and elastase - alpha 1-antitrypsin (显示 SERPINA1 蛋白) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (显示 SLC44A2 蛋白) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.
Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (显示 CEBPA 蛋白)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (显示 CEBPA 蛋白) are resistant to HFD-induced myelopoiesis.
Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).
Serine protease (显示 F2 蛋白) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock
Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration
results of ultrasound studies using the elastase and AngII apoE (显示 APOE 蛋白) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
SerpinA3N (显示 SERPINA3N 蛋白) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.
In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
, bone marrow serine protease
, elastase 2, neutrophil
, granulocyte-derived elastase
, human leukocyte elastase
, leukocyte elastase
, neutrophil elastase
, polymorphonuclear elastase
, serine protease
, elastase, neutrophil expressed
, LOW QUALITY PROTEIN: neutrophil elastase