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The protein encoded by ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. 再加上，我们可以发ELF5 蛋白 (5) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal ELF5 Primary Antibody for IHC (p), IHC - ABIN249582
Oettgen, Kas, Dube, Gu, Grall, Thamrongsak, Akbarali, Finger, Boltax, Endress, Munger, Kunsch, Libermann: Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. in The Journal of biological chemistry 1999
Downregulation of ELF5 increases the expression of AR-response genes and the progression of prostate cancer. ELF5 interaction with AR is androgen dependent.
Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 (显示 AQP2 抗体) and Avpr2 (显示 AVPR2 抗体) genes.
Mechanistically, RL negatively regulates Stat5 (显示 STAT5A 抗体) phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (显示 PRL 抗体)/p-Stat5 (显示 STAT5A 抗体) pathway.
Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC (显示 SLC12A3 抗体) proliferation and differentiation
Elf5 and Ets2 (显示 ETS2 抗体) maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 (显示 SOX2 抗体) and 3 and inhibiting Hand1 (显示 HAND1 抗体) expression.
Blockade of RankL (显示 TNFSF11 抗体) action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells.
Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.
Studies suggest that Elf5 loss leads to hyperactivation of the Notch (显示 NOTCH1 抗体) signaling pathway, which might constitute in part, the underlying molecular mechanism for the altered cell lineage decisions in Elf5-null mammary epithelial cells.
Elf5 promoter methylation is regulated during mammary differentiation in vivo.
Elf5 expression was associated with decreased overall and disease-free survival of triple negative breast cancers patients.
When ELF5 was transfected into the parental MCF7 cells that lack CEACAM1 (显示 CEACAM1 抗体), lumen formation was restored, indicating that ELF5 can replace CEACAM1 (显示 CEACAM1 抗体) in this model system of lumenogenesis.
These results support the contention that ABO (显示 ABO 抗体) expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells.
Low ELF5 expression is associated with ovarian cancer.
The results of this study suggest that ELF5 is a candidate gene that confers genetic susceptibility for pediatric asthma in the Taiwanese population and SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.
a novel EWSR1 (显示 EWSR1 抗体)/ETS (显示 ETS1 抗体) chimeric gene, was identified in a patient diagnosed with refractory AML (显示 RUNX1 抗体), suggesting a potential role of leukemogenesis in rare cases of AML (显示 RUNX1 抗体). This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53 (显示 TP53 抗体)/p21 (显示 CDKN1A 抗体)-dependent pathway.
Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms.
Data (including data from studies in transgenic mice) suggest that expression of ELF5 in luminal breast cancer correlates with increased myeloid cell invasion, inflammation, and lung metastasis.
we identified Elf5 as a novel biomarker of urothelial cancer on several biological levels and established a causative link between Elf5 and epithelial-mesenchymal transition in urothelial cancer.
Elf5 expression is inversely correlated with epithelial-mesenchymal transition in prostate cancer.
Elf5 regulation in the trophectoderm
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
E74-like factor 5 (ets domain transcription factor)
, ETS-related transcription factor Elf-5
, Epithelium specific Ets-2
, epithelium-restricted ESE-1-related Ets factor
, epithelium-specific Ets transcription factor 2
, E74-like factor 5 ESE-2a