Dual Specificity Phosphatase 2 (DUSP2) ELISA试剂盒

The protein encoded by DUSP2 is a member of the dual specificity protein phosphatase subfamily. 再加上,我们可以发DUSP2 抗体 (30)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
DUSP2 1844 Q05923
DUSP2 13537 Q05922
大鼠 DUSP2 DUSP2 311406  
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Human Dual Specificity Phosphatase 2 (DUSP2) interaction partners

  1. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 has been reported.

  2. hypoxia-induced IL-6 production in endometriotic lesions is mediated via downregulation of DUSP2, which causes aberrant activation of STAT3 signaling pathway and helps the endometriotic cells survive under the ectopic environment

  3. Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer.

  4. Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8, which facilitates angiogenesis and tumour metastasis.

  5. Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression.

  6. Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma.

  7. identified among the key genes in circulating monocytes that were altered by exercise

  8. Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2).

  9. DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis.

  10. Dipyridamole reduced expression of PAC-1 and CD62p in patients with malignant lymphoma.

  11. DUSP2 is a key downstream regulator of HIF-1-mediated tumor progression and chemoresistance

  12. During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter

  13. relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation

  14. variation in large granular lymphocyte leukemia

  15. These results reveal a crucial role of PAC1 in E2F-1-directed apoptosis.

  16. a novel, stimulus-specific, and phosphatase-specific mechanism of ERK2 regulation in the nucleus by DUSP1, -2, and -4.

  17. Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker PAC-1 or the number of circulating platelet-leucocyte aggregates.

Mouse (Murine) Dual Specificity Phosphatase 2 (DUSP2) interaction partners

  1. Data indicate that dual specificity phosphatase 2 protein (DUSP2) is a true STAT3 transcription factor phosphatase that modulates the development of TH17 cells in the autoimmune response and inflammation.

  2. DUSP2 plays no role in regulating obesity-associated inflammation and only a minor role in controlling insulin sensitivity following high-fat diet in female, but not male, mice.

  3. the expression of PAC1 in the thymus changes in reverse ratio with thymus index and in direct ratio with cell apoptosis and only low dose of PACAP had positive effects against the CPS-induced thymus atrophy.

  4. Arg294 and Arg295 play an important role in PAC-1 catalytic activation induced by ERK2 binding

DUSP2 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

Gene names and symbols associated with DUSP2

  • dual specificity phosphatase 2 (dusp2) 抗体
  • dual specificity phosphatase 2 (DUSP2) 抗体
  • dual specificity phosphatase 2 (Dusp2) 抗体
  • PAC-1 抗体
  • PAC1 抗体
  • wu:fj40g04 抗体
  • zgc:91929 抗体

Protein level used designations for DUSP2

dual specificity protein phosphatase 2 , dual specificity protein phosphatase PAC-1 , dual-specificity phosphatase 2 , serine/threonine specific protein phosphatase

445057 Danio rerio
1844 Homo sapiens
13537 Mus musculus
311406 Rattus norvegicus
611653 Canis lupus familiaris
539140 Bos taurus
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