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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. 再加上，我们可以发DUSP1 试剂盒 (30) 和 DUSP1 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368
Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016
Show all 2 Pubmed References
Human Monoclonal DUSP1 Primary Antibody for IF, ELISA - ABIN515099
Chao, Sun, Peng, Wu: Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells. in International journal of molecular sciences 2016
Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653
Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993
Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
this work indicates that suppression of JNK1 (显示 MAPK8 抗体)/2 activity by MKP-1 maintains PARP-1 (显示 PARP1 抗体) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (显示 PARP1 抗体) inhibition.
Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.
Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.
Increased MAP2K6 (显示 MAP2K6 抗体), MAP4K3 (显示 MAP4K3 抗体), and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.
The aim of this review is to shed light on the role of four different phosphatases (PTEN (显示 PTEN 抗体), PP2A (显示 PPP2R4 抗体), CDC25 (显示 RASGRF1 抗体) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.
The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.
we show that IL-1 (显示 IL1A 抗体) induces robust p38a (显示 MAPK14 抗体) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (显示 MAPK14 抗体) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 (显示 TAB1 抗体) and MKP1 through a positive feedback loop.
Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.
Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK (显示 MAPK14 抗体)-mediated overexpression of p-glycoprotein in human ovarian cancer cells.
MKP-1 regulates IL-1beta (显示 IL1B 抗体) production through stabilization of HIF-1alpha (显示 HIF1A 抗体). The induction of HIF-1alpha (显示 HIF1A 抗体) protein in MKP-1 deficiency is partly due to p38MAPK (显示 MAPK14 抗体) activation in response to LPS (显示 TLR4 抗体).
this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.
c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (显示 TYRO3 抗体) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.
PTHrP (显示 PTHLH 抗体) counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (显示 ADORA2A 抗体) signaling regulates both basal and LPS (显示 TLR4 抗体)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (显示 MAPK1 抗体) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (显示 NR4A1 抗体) induction is dependent on ERK1/2 (显示 MAPK1/3 抗体) and that MKP-1 negatively regulates this induction.
MKP-1 negatively regulates chemokine (显示 CCL1 抗体)-driven osteoclast formation and subsequent bone resorption in response to LPS (显示 TLR4 抗体) stimulation
results suggest that the p38alpha (显示 MAPK14 抗体)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (显示 MAPK1/3 抗体)-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (显示 FYN 抗体) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (显示 MAPK1 抗体) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1