anti-Dual Specificity Phosphatase 1 (DUSP1) 抗体

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. 再加上,我们可以发DUSP1 试剂盒 (30)DUSP1 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DUSP1 1843 P28562
DUSP1 114856 Q64623
DUSP1 19252 P28563
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antibodies-online.cn销售最多的anti-DUSP1 抗体

Showing 10 out of 134 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 ELISA, IHC ABIN184638 (3.8µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. ABIN184638 (0.3µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
小鸡 非结合性 IHC, WB Immunohistochemical analysis of DUSP1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of DUSP1 expression in HeLa (A) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using MKP1 (Ab-359) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MKP1 (Ab-359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using MKP1 (Phospho-Ser359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$484.00
详细
Cow 山羊 非结合性 IHC (p), WB   0.1 mg Log in to see 4至8个工作日
$462.00
详细
山羊 非结合性 IHC (p), IHC, ELISA, WB ABIN257653 staining (2µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane). Western Blot: MKP-1/DUSP1 Antibody [ABIN257653] - (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7至9个工作日
$488.73
详细
Bat 山羊 非结合性 ELISA, IHC, IHC (p), WB Human Prostate (formalin-fixed, paraffin-embedded) stained with DUSP1 antibody ABIN351458 at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-DUSP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml. 50 μg Log in to see 11至14个工作日
$484.00
详细
非结合性 IHC, IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with DUSP1 antibody ABIN337195 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-DUSP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11至14个工作日
$727.83
详细
山羊 非结合性 EIA, IHC (p), WB 50 μg Log in to see 6至8个工作日
$495.00
详细

引用最多的anti-DUSP1 抗体

  1. Human Polyclonal DUSP1 Primary Antibody for ELISA, WB - ABIN545088 : Chandrasekharan, Yang, Walters, Howe, DiCorleto: Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368 : Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519 : Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014 (PubMed)

  4. Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653 : Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993 (PubMed)

  5. Human Monoclonal DUSP1 Primary Antibody for IF, ELISA - ABIN515099 : Chao, Sun, Peng, Wu: Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells. in International journal of molecular sciences 2016 (PubMed)

更多抗DUSP1的相互作用对抗体

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1

  2. Study reports the crystal structure of the human DUSP1 catalytic domain at 2.49 A resolution. The protein was crystallized as a (maltose-binding protein) MBP fusion protein in complex with a monobody that binds to MBP. Sulfate ions occupy the phosphotyrosine and putative phosphothreonine binding sites in the DUSP1 catalytic domain.

  3. The molecular structure of DUSP1 crystallized as MBP fusion protein has been reported.

  4. High DUSP1 expression is associated with apatinib resistance by activating the MAPK pathway in gastric cancer.

  5. SIN attenuated LPS-induced inflammatory injury by regulation of miR-101, MKP-1 and JNK pathway.

  6. miR-202-3p is upregulated in type 1 gastric neuroendocrine neoplasms (g-NENs) lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1.

  7. Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2.

  8. the expression of DUSP1 was lower in OA FLSs than in normal FLSs, and DUSP1 may inhibit the expression of OA-associated mediators, MMP-13 and COX-2, by suppressing the activation of p38 MAPK and JNK pathways in OA FLSs.

  9. Curcumin suppressed CXCL5 expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK via induction of negative regulator MKP-1.

  10. MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review)

  11. We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC cells.

  12. this work indicates that suppression of JNK1/2 activity by MKP-1 maintains PARP-1 levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 inhibition.

  13. Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.

  14. Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.

  15. Increased MAP2K6, MAP4K3, and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.

  16. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

  17. Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.

  18. The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.

  19. we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop.

  20. Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. this study shows that Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response

  2. Results provide evidence that Mkp-1 plays an important role in the regulation of both the inflammatory response and metabolic programming during host defense against bacterial infection.

  3. Results indicate that the upregulation of anterior cingulate cortex (ACC, areas 24a and 24b) MKP-1 is necessary for the expression of depressive symptoms induced by chronic pain, chronic stress, and optogenetic activation of the ACC.

  4. The results suggested that DUSP1 gene silencing promoted the release of proinflammatory cytokines through activation of the MAPK signaling pathway in mice with acute pancreatitis.

  5. The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK which upregulated the expression of the mitochondrial fission factor (Mff).

  6. Study demonstrates that MKP-1 serves as a master-regulator of macrophage phenotype and function and its dysregulation by metabolic stress may be a major contributor to atherogenesis and the progression of atherosclerotic plaques.

  7. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling.

  8. these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic

  9. MKP-1 regulates IL-1beta production through stabilization of HIF-1alpha. The induction of HIF-1alpha protein in MKP-1 deficiency is partly due to p38MAPK activation in response to LPS.

  10. this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.

  11. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.

  12. PTHrP counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.

  13. A2AR signaling regulates both basal and LPS-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.

  14. these data suggest an important role for DUSPs in regulating MAPK dephosphorylation, with an emphasis on DUSP1, during early adipogenesis

  15. Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.

  16. Nr4a1 induction is dependent on ERK1/2 and that MKP-1 negatively regulates this induction.

  17. MKP-1 negatively regulates chemokine-driven osteoclast formation and subsequent bone resorption in response to LPS stimulation

  18. results suggest that the p38alpha-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.

  19. DUSP1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide.

  20. MKP-1 regulated the expression of MMP-12.

Pig (Porcine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC activity, which, in turn, increases MKP-1 activity and maintains MAPK1 activity at submaximal values.

DUSP1 抗原简介

蛋白简介

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1) 抗体
  • dual specificity phosphatase 1 (Dusp1) 抗体
  • dual specificity phosphatase 1 (dusp1) 抗体
  • dual specificity phosphatase 1 S homeolog (dusp1.S) 抗体
  • 3CH134 抗体
  • cb269 抗体
  • CL100 抗体
  • DUSP1 抗体
  • erp 抗体
  • HVH1 抗体
  • id:ibd2586 抗体
  • mkp-1 抗体
  • Mkp1 抗体
  • PTPN10 抗体
  • Ptpn16 抗体
  • sb:cb269 抗体
  • U19515 抗体
  • wu:fd19g02 抗体
  • wu:fe50g09 抗体
  • XCL100 抗体
  • zgc:55920 抗体

Protein level used designations for DUSP1

MAP kinase phosphatase 1 , dual specificity protein phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , dual specificity phosphatase 1 , mitogen-activated protein kinase phosphatase-1 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , mkp-1 , MAPK phosphatase 1 , LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 , MAP kinase phosphatase XCL100(beta) protein , XCL100-beta , dual specificity protein phosphatase 1-B , dusp1-b

GENE ID SPECIES
1843 Homo sapiens
114856 Rattus norvegicus
374192 Gallus gallus
471742 Pan troglodytes
539175 Bos taurus
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
19252 Mus musculus
406340 Danio rerio
100522469 Sus scrofa
489117 Canis lupus familiaris
100725668 Cavia porcellus
398254 Xenopus laevis
101107632 Ovis aries musimon
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