anti-Desmin (DES) 抗体

DES encodes a muscle-specific class III intermediate filament. 再加上,我们可以发Desmin 试剂盒 (73)Desmin 蛋白 (30)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DES 1674 P17661
DES 64362 P48675
DES 13346 P31001
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antibodies-online.cn销售最多的anti-Desmin 抗体

Showing 10 out of 406 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IHC (fro), IHC (p), WB Anti-Desmin Picoband antibody,  IHC(F): Rat Cardiac Muscle Tissue Anti-Desmin Picoband antibody,  All lanes: Anti Desmin  at 0.5ug/ml WB: Recombinant Human Desmin Protein 0.5ng Predicted bind size: 36KD Observed bind size: 36KD 100 μg 4至6个工作日
$280.00
详细
小鼠 非结合性 IHC (p), WB Anti-Desmin antibody (monoclonal), IHC(P) IHC(P): Rat Cardiac Muscle Tissue Anti-Desmin antibody (monoclonal), IHC(P): Rat Cardiac Muscle Tissue 100 μg 4至6个工作日
$280.00
详细
Cow 非结合性 WB WB Suggested Anti-DES Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Muscle Host:  Rabbit  Target Name:  DES  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml 100 μL 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, WB ABIN334386 (0.2µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6至7个工作日
$429.84
详细
小鸡 非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日
$329.45
详细
非结合性 IHC (p), WB IHC-P Image Desmin antibody detects Desmin protein at cytosol on mouse skeletal muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse skeletal muscle. Desmin antibody , dilution: 1:500. WB Image Desmin antibody detects Desmin protein by western blot analysis. A. 30 μg Rat2 whole cell lysate/extract 10 % SDS-PAGE Desmin antibody , dilution: 1:1000 100 μL 3至4个工作日
$466.18
详细
Cow 非结合性 WB WB Suggested Anti-DES Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate Host:  Mouse  Target Name:  DES  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL 2至3个工作日
$229.00
详细
小鸡 非结合性 IC, IF, IHC, WB Immunofluorescent analysis of Desmin staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Desmin staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13至14个工作日
$487.50
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from K562 cells, using Desmin Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using Desmin Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2至3个工作日
$302.50
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from HeLa/HepG2 cells, using Desmin (Ab-60) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Desmin (Ab-60) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2至3个工作日
$302.50
详细

引用最多的anti-Desmin 抗体

  1. Human Polyclonal Desmin Primary Antibody for IHC (fro), IHC (p) - ABIN3043265 : Jiang, Xu, Zhu, Chen, Qian, Qiao, Yang, Wang, Chen: Histological type of oncogenity and expression of cell cycle genes in tumor cells from human mesenchymal stem cells. in Oncology reports 2006 (PubMed)
    Show all 22 Pubmed References

  2. Human Monoclonal Desmin Primary Antibody for IHC (p), WB - ABIN3043640 : Longxi, Buwu, Yuan, Sinan: Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. in PLoS ONE 2011 (PubMed)
    Show all 22 Pubmed References

  3. Human Monoclonal Desmin Primary Antibody for IHC (fro), IHC - ABIN335360 : Dispersyn, Geuens, Ver Donck, Ramaekers, Borgers: Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts. in Cardiovascular research 2001 (PubMed)
    Show all 8 Pubmed References

  4. Chicken Polyclonal Desmin Primary Antibody for IF (p), IHC (p) - ABIN736566 : Luo, Wu, Ye, Li, Hao, Kong, Zheng, Lin, Nie, Zhang: The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation. in Cell death & disease 2014 (PubMed)
    Show all 6 Pubmed References

  5. Polyclonal Desmin Primary Antibody for IHC (fro), IP - ABIN540924 : Kitamura, Ando, Shibata, Tanabe, Sato, Inagaki: Protein kinase C phosphorylation of desmin at four serine residues within the non-alpha-helical head domain. in The Journal of biological chemistry 1989 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal Desmin Primary Antibody for ELISA, IHC - ABIN4304973 : Raghuvanshi, Reed, Blaner, Harrison: Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine. in Archives of biochemistry and biophysics 2015 (PubMed)
    Show all 2 Pubmed References

  7. Cat (Feline) Monoclonal Desmin Primary Antibody for ICC, IF - ABIN257974 : Agarwal, van den Born, van Goor, Navis, Gans, Bakker: Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria. in American journal of physiology. Renal physiology 2012 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal Desmin Primary Antibody for IHC, WB - ABIN6714474 : Qian, Qian, Zhang, Zhu, Yan, Ye, Peng, Li, Xu, Sun, Xu: 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. in Stem cells and development 2012 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN969477 : Shardonofsky, Capetanaki, Boriek: Desmin modulates lung elastic recoil and airway responsiveness. in American journal of physiology. Lung cellular and molecular physiology 2006 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN965993 : Huang, Li, Foster, Lemanski, Dube, Zhang, Lemanski: Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. in Experimental biology and medicine (Maywood, N.J.) 2002 (PubMed)
    Show all 2 Pubmed References

更多抗Desmin的相互作用对抗体

Zebrafish Desmin (DES) interaction partners

  1. Desmin intermediate filaments are required for normal active force generation.

  2. Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated afterwards.

Human Desmin (DES) interaction partners

  1. The DES-p.Glu401Asp mutation causes predominant inherited left ventricular arrhythmogenic cardiomyopathy/dysplasia with a high incidence of adverse clinical events in the absence of skeletal myopathy or conduction system disorders.

  2. There was no association of any of the rs1058261 genotypes with hypertension at the age of 50. At age of 60, after adjustment for gender and body mass index, subjects with the genotype CC had higher incidence of cerebrovascular events compared with the T allele (1.6%) (p = 0.046). In addition, those with CC genotype had a higher incidence of all combined cardiovascular events compared with subjects with the T allele.

  3. A novel mutation (c.679 C>T /p.R227C) in exon 3 of DES was identified and cosegregated with the affected members of a Chinese family with isolated Dilated cardiomyopathy (DCM) phenotypes (left ventricle and left atrial diameters).

  4. Desmin, Glial Fibrillary Acidic Protein, Vimentin, and Peripherin are type III intermediate filaments that have roles in health and disease [review]

  5. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.

  6. Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin filaments, this study shows that the binding of CRYAB to desmin is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin.

  7. Targeted sequencing revealed trigenic mutations: c.700G>A/p.E234K in DES, c.2966G>A/p.R989H in MYPN, and c.5918G>C/p.R1973P in CACNA1C in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome.

  8. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  9. Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity

  10. Data show that the filament elongation of both desmin and keratin K8/K18 proceeds very similar to that of vimentin.

  11. Cdk1-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  12. Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.

  13. Ile367Phe, Pro419Ser, and Arg415Glu mutations were associated with desminopathy causing cardiomyopathy in 4 families studied.

  14. Increasing desmin abnormalities were correlated with diastolic dysfunction progression.

  15. expression level of mutant versus wild-type desmin in mouse model as well as in skeletal muscle specimens derived from human R350P desminopathies; findings demonstrate missense-mutant desmin inflicts changes of the subcellular localization and turnover of desmin itself and of direct desmin-binding partners

  16. Results propose that the mutations affect desmin structure and cause its aberrant folding and subsequent aggregation, triggering disruption of myofibrils organization.

  17. identified disruption of the desmin system in gastrocnemius myofibers as an index of the myopathy and limitation of muscle function in patients with peripheral artery disease.

  18. The desmin intermediate filament network plays a major role in striated muscle development and maintenance by integrating and coordinating most cellular components necessary for proper mechanochemical signaling, organelle cross-talk, energy production and trafficking processes required for proper tissue homeostasis. [Review]

  19. Data suggest that loss of the desmin-p. A120D filament localization at the intercalated disk indicates its clinical arrhythmogenic potential.

  20. we describe a new mutation located in the coiled 1B domain of desmin and associated with a predominant cardiac involvement and a high degree of cardiac sudden death in a large Indian pedigree with 12 affected members

Mouse (Murine) Desmin (DES) interaction partners

  1. Data suggest that mutated desmin markedly impedes myocyte structure and function at pre-symptomatic stages of myofibrillar myopathies.

  2. Moderate MnSOD and/or catalase overexpression in desmin-null hearts leads to a marked decrease in intracellular reactive oxygen species, ameliorates mitochondrial and other ultrastructural defects, minimizes myocardial degeneration and leads to a significant improvement of cardiac function.

  3. R349P mutant desmin-related remodeling of the 3D myofibrillar architecture during aging, which provides a structural basis for the progressive muscle weakness.

  4. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  5. The disease-mutant desmin variants E245D and T453I exhibited increased binding affinity for nebulette, delayed filament assembly kinetics, and caused significant weakening of networks.

  6. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

  7. Complete lack or markedly decreased expression of mutant R349P desmin impairs the structural and functional integrity of neuromuscular endplates.

  8. Cdk1-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  9. the coordinated up-regulations of desmin and alpha- actinin specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  10. E413K mutation induces desmin network disorganization, desmin aggregate formation and alters the traction forces generation of single myoblasts.

  11. This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients

  12. found that inhibition of the Rac1 pathway (a G protein signaling pathway involved in diverse cellular processes), antioxidant treatment, and stimulation of macroautophagy reduced desmin aggregation by up to 75% in this model

  13. This demonstration of biomechanical integration by the desmin intermediate filament system suggests that it plays an active biological role in muscle in addition to its accepted structural role

  14. expression level of mutant versus wild-type desmin in mouse model as well as in skeletal muscle specimens derived from human R350P desminopathies; findings demonstrate missense-mutant desmin inflicts changes of the subcellular localization and turnover of desmin itself and of direct desmin-binding partners

  15. Disruption of both nesprin 1 and desmin results in decreased lifespan, body weight and muscle strength.

  16. The desmin intermediate filament network plays a major role in striated muscle development and maintenance by integrating and coordinating most cellular components necessary for proper mechanochemical signaling, organelle cross-talk, energy production and trafficking processes required for proper tissue homeostasis. [Review]

  17. Desmin content and transversal stiffness of the left ventricle mouse cardiomyocytes and skeletal muscle fibers after a 30-day space flight on board "BION-M1" biosatellite

  18. the observed decline in [Ca(2+)]mit was due to desmin aggregate accumulation resulting in the loss of desmin mitochondria interactions

  19. expression detected specifically in the mylohyoid, strong expression evident after embryonic day 13, increased with age

  20. During fasting, desmin phosphorylation increases and enhances Trim32-mediated degradation of the desmin cytoskeleton, which appears to facilitate the breakdown of Z-bands and thin filaments.

Cow (Bovine) Desmin (DES) interaction partners

  1. Results show that expression of desmin increased during the late fattening stage of of hanwoo steers and it contributes to the muscle contractile apparatus.

Desmin (DES) 抗原简介

蛋白简介

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Gene names and symbols associated with anti-Desmin (DES) 抗体

  • desmin (DES) 抗体
  • desmin, gene 1 L homeolog (des.1.L) 抗体
  • desmin, gene 1 (des.1) 抗体
  • desmin (des) 抗体
  • desmin a (desma) 抗体
  • desmin (Des) 抗体
  • desmin b (desmb) 抗体
  • desmin, gene 1 S homeolog (des.1.S) 抗体
  • desmin, gene 2 S homeolog (des.2.S) 抗体
  • cb290 抗体
  • cmd1i 抗体
  • CSM1 抗体
  • CSM2 抗体
  • des 抗体
  • des-a 抗体
  • des-b 抗体
  • desm 抗体
  • desmin 抗体
  • fb59a12 抗体
  • LGMD2R 抗体
  • LOC100220724 抗体
  • MGC52614 抗体
  • MGC75911 抗体
  • MGC80853 抗体
  • wu:fb59a12 抗体
  • wu:fc11d08 抗体
  • zgc:109859 抗体
  • zgc:154009 抗体

Protein level used designations for anti-Desmin (DES) 抗体

desmin , desmin, gene 1 , desmin-like , intermediate filament protein , muscle-specific intermediate filament desmin , fc11d08

GENE ID SPECIES
100059397 Equus caballus
100137488 Papio anubis
446868 Xenopus laevis
394739 Xenopus (Silurana) tropicalis
470657 Pan troglodytes
100136041 Oncorhynchus mykiss
100220724 Taeniopygia guttata
100402007 Callithrix jacchus
30148 Danio rerio
100586972 Nomascus leucogenys
395906 Gallus gallus
1674 Homo sapiens
64362 Rattus norvegicus
497091 Canis lupus familiaris
13346 Mus musculus
101097010 Felis catus
280765 Bos taurus
101117308 Ovis aries
100328890 Oryctolagus cuniculus
396725 Sus scrofa
100733478 Cavia porcellus
101837949 Mesocricetus auratus
768287 Danio rerio
379869 Xenopus laevis
733312 Xenopus laevis
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