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Deoxyuridine Triphosphatase (DUT) ELISA试剂盒

DUT encodes an essential enzyme of nucleotide metabolism. 再加上，我们可以发Deoxyuridine Triphosphatase 抗体 (116) 和 Deoxyuridine Triphosphatase 蛋白 (87)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
DUT 1854 P33316
抗小鼠 DUT DUT 110074  
DUT 497778 P70583
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Fruit Fly (Drosophila melanogaster) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. revealed the importance of the PAA(10-12) tripeptide and the ID(17-18) dipeptide, as well as the role of the PAAK(10-13) segment in nuclear localization of dUTPase.

  2. there is a conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer

  3. kinetic characterization, folding, and crystallographic studies of dUTPase

  4. dUTPase is developmentally regulated in Drosophila melanogaster

  5. dUTPase, a recently described eukaryotic model, has a similar affinity of binding towards alpha,beta-imino-dUTP as compared to the prokaryotic E. coli enzyme

  6. dUTPase localization character showed strict timing to the nuclear cleavage phases and explained how its isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle.

Human Deoxyuridine Triphosphatase (DUT) interaction partners

  1. A single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene was associated with a syndrome of bone marrow failure and diabetes.

  2. Comparison of the cellular distribution of wild-type dUTPase with those of hyperphosphorylation- and hypophosphorylation-mimicking mutants suggests that phosphorylation at Ser11 leads to the exclusion of dUTPase from the nucleus.

  3. EBV-encoded dUTPase may act as an intercellular signaling molecule capable of modulating the cellular microenvironment

  4. Data sugget that inhibition of dUTPase is a mechanism-based therapeutic approach to significantly enhance the efficacy of thymidylate synthase (TS)-targeted chemotherapeutic agents.

  5. Repression of dUTPase induced specific expression level increments for thymidylate kinase and thymidine kinase, and also an increased sensitization to 5-fluoro-2'-deoxyuridine and 5-fluoro-uracil.

  6. High dUTP pyrophosphatase is associated with recurrence in colorectal cancer patients undergoing 5-fluorouracil adjuvant chemotherapy

  7. nuclear dUTPase may be a good biomarker for predicting prognosis in HCC patients after surgical resection

  8. significant differences between the human and Plasmodium dUTPases

  9. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

  10. Nuclear dUTPase may contain a complex nuclear localization signal that is located throughout the entire protein.

  11. dUTPase staining provides a useful measure of cell proliferation distinct from that offered by Ki-67 labeling. It proved particularly useful for the evaluation of diffuse astrocytomas.

  12. kinetic model of the human dUTPase catalytic cycle

  13. determined the crystal structure of the enzyme:alpha,beta-imino-dUTP

  14. Establishment of a direct role for both mutant and wild-type forms of p53 in modulating dUTPase promoter activity.

  15. hinge proline destabilize human and Escherichia coli dUTPases without preventing trimeric organization

Mouse (Murine) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

Deoxyuridine Triphosphatase (DUT) 抗原简介

Antigen Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Gene names and symbols associated with DUT

  • deoxyuridine triphosphatase (DUT) 抗体
  • Deoxyuridine triphosphatase (dUTPase) 抗体
  • deoxyuridine triphosphatase (P18) 抗体
  • dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51) 抗体
  • deoxyuridine triphosphatase (UL50) 抗体
  • deoxyuridine triphosphatase (HVT058) 抗体
  • involved in nucleotide metabolism (UL50) 抗体
  • deoxyuridine triphosphatase (ORF9) 抗体
  • deoxyuridine triphosphatase (ORF8) 抗体
  • tegument protein (U45) 抗体
  • dUTPase (GAMMAHV.ORF54) 抗体
  • deoxyuridine triphosphatase (Tc00.1047053509151.130) 抗体
  • deoxyuridine triphosphatase (Tc00.1047053508175.160) 抗体
  • deoxyuridine triphosphatase (Tb927.7.5160) 抗体
  • deoxyuridine triphosphatase L homeolog (dut.L) 抗体
  • deoxyuridine triphosphatase (Dut) 抗体
  • 5031412I06Rik 抗体
  • 5133400F09Rik 抗体
  • anon-SAGE:Wang-077 抗体
  • BcDNA:LD08534 抗体
  • CG4584 抗体
  • D2Bwg0749e 抗体
  • Dmel\\CG4584 抗体
  • Dutp 抗体
  • dutpase 抗体
  • LD08534 抗体
  • PIP4 抗体
  • Tb07.27E10.390 抗体
  • UTPase 抗体

Protein level used designations for DUT

dUTP pyrophosphatase , CG4584-PA , CG4584-PB , CG4584-PC , CG4584-PD , anon-SAGE:Wang-077 , dUTPase-PA , dUTPase-PB , dUTPase-PC , dUTPase-PD , deoxyuridine triphosphatase , deoxyuridine 5'-triphosphate nucleotidohydrolase , deoxyuridine triphosphatase, dUTPase, P18 , dUTP nucleotidohydrolase , deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial , PPAR-interacting protein 4 , dUTPase

GENE ID SPECIES
714401 Macaca mulatta
34529 Drosophila melanogaster
544274 Solanum lycopersicum
911778 Alcelaphine herpesvirus 1
911900 Gallid herpesvirus 3
918521 Meleagrid herpesvirus 1
1487339 Human herpesvirus 2
1487399 Bovine herpesvirus 1
1487647 Equid herpesvirus 4
1487671 Human herpesvirus 3
1487924 Human herpesvirus 6A
1497169 Murid herpesvirus 4
2703421 Human herpesvirus 1
3545542 Trypanosoma cruzi strain CL Brener
3553795 Trypanosoma cruzi strain CL Brener
3658718 Trypanosoma brucei brucei strain 927/4 GUTat10.1
100037200 Xenopus laevis
1854 Homo sapiens
609526 Canis lupus familiaris
110074 Mus musculus
497778 Rattus norvegicus
507945 Bos taurus
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