anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) 抗体

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. 再加上,我们可以发DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 试剂盒 (8)DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • 在线下订单
  • orders@antibodies-online.cn

antibodies-online.cn销售最多的anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 抗体

Showing 10 out of 81 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL Log in to see 3至4个工作日
$466.18
详细
小鼠 非结合性 IF, ELISA, WB Detection limit for recombinant GST tagged DOT1L is approximately 0.03ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to DOT1L on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11至12个工作日
$440.00
详细
非结合性 IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-DOT1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3至7个工作日
$317.90
详细
非结合性 ELISA, WB Western blot analysis of DOT1L expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11至12个工作日
$390.77
详细
非结合性 ELISA, WB   100 μL Log in to see 11至13个工作日
$335.04
详细
小鼠 非结合性 IHC, IHC (p), WB   100 μL Log in to see 11至14个工作日
$522.50
详细
小鼠 非结合性 WB   100 μL Log in to see 11至14个工作日
$522.50
详细
小鼠 非结合性 WB   100 μL Log in to see 11至14个工作日
$522.50
详细
小鼠 非结合性 IHC, IHC (p), WB   100 μL Log in to see 11至14个工作日
$522.50
详细
非结合性 WB Western blot analysis of extracts of HeLa cells, using DOT1L antibody (ABIN5974758) at 1/1000 dilution. 100 μL Log in to see 11至16个工作日
$426.40
详细

引用最多的anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 抗体

  1. Human Polyclonal DOT1L Primary Antibody for ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal DOT1L Primary Antibody for IHC (p) - ABIN6243177 : Comty, Wathen, Shapiro: Uremic pericarditis. in Cardiovascular clinics 1977 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal DOT1L Primary Antibody for IF, ELISA - ABIN566567 : Phillips, Wildt, Comizzoli: Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis. in Journal of assisted reproduction and genetics 2016 (PubMed)

  4. Human Polyclonal DOT1L Primary Antibody for ICC, IF - ABIN251530 : Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011 (PubMed)

更多抗DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae)的相互作用对抗体

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. The present study identifies H3K79me1 and DOT1L upregulation as a novel epigenetic signature of arsenic-exposed humans who have characteristic dermatological lesions.

  2. DOT1L limits Wnt signalling to maintain cartilage homeostasis and protects against osteoarthritis.

  3. DOT1L is essential for activation of NKX2.5 during the cardiac differentiation of human embryonic stem cells.

  4. Each C-Nap1 ring at the proximal end of the two centrioles organizes a rootletin ring and, in addition, multiple rootletin/CEP68 fibers.

  5. Gene and protein expression of DOT1L was increased in synovial tissues of both osteoarthritis and rheumatoid arthritis patients.

  6. human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase DNMT3A and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L.

  7. this study shows that Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma

  8. facilitates DNA damage repair; plays a protective role in ultraviolet radiation-induced melanomagenesis

  9. DOT1L cooperates with transcription factor ETS-1 to stimulate the expression of VEGFR2, thereby activating ERK1/2 and AKT signaling pathways and promoting angiogenesis.

  10. findings demonstrate that DOT1L over-expression has important clinical significance in ovarian cancer and also clarify that it drives cell cycle progression through transcriptional regulation of CDK6 and CCND3 through H3K79 methylation

  11. MLL-AF4 spreading gene expression is downregulated by inhibitors of the H3K79 methyltransferase DOT1L.

  12. our results identify DOT1L as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma.

  13. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  14. this indicates that DOT1L function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  15. DOT1L may play a critical role in DNMT3A-mutant leukemia.

  16. DOT1L, via dimethylated histone H3 K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.

  17. study demonstrates the development of potent DOT1L inhibitors with novel scaffolds

  18. these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 production leading to up-regulation of RhoGTPase and survival proteins.

  19. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  20. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. The inhibition of DOT1L or DUSP6 overexpression in T cells attenuates the development of graft-versus-host disease, while retaining potent antitumor activity in xenogeneic and allogeneic adoptive immunotherapy models.

  2. DOT1L limits Wnt signalling to maintain cartilage homeostasis and protects against osteoarthritis.

  3. In the absence of DOT1L, ultraviolet radiation (UVR)-induced DNA damage is inefficiently repaired, so that DOT1L loss promotes melanoma development after exposure to UVR.

  4. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  5. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  6. DOT1L may play a critical role in DNMT3A-mutant leukemia.

  7. DOT1L, via dimethylated histone H3 K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.

  8. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 is a new transcriptional target of Dot1l.

  9. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  10. Interference with DOT1L activity resulted in transcriptional activation of Atf4 and Ddit3 accompanied by decreased levels of H3K79 dimethylation.

  11. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

  12. DOT1L has a role in inhibiting SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

  13. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

  14. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  15. The cytological distribution of the evolutionarily conserved DOT1L methyltransferase and the different H3K79 methylation states resulting from its activity during meiotic prophase I in mouse spermatocytes.

  16. The absence of DOT1L, which is involved in the formation of a specific configuration of heterochromatin at the two-cell stage, is essential for early preimplantation development.

  17. Impaired alphaENaC expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  18. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack.

  19. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  20. Upregulated Aqp5 may contribute to polyuria, possibly by impairing Aqp2 membrane localization, in Dot1l(AC) mice and in patients with diabetic nephropathy.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) 抗原简介

蛋白简介

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC100116648) 抗体
  • DOT1 like histone lysine methyltransferase (DOT1L) 抗体
  • histone methyltransferase (DOT1) 抗体
  • DOT1 like histone lysine methyltransferase (Dot1l) 抗体
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) 抗体
  • A630076O07 抗体
  • AW907654 抗体
  • Dot1 抗体
  • DOT1L 抗体
  • KMT4 抗体
  • mDot1 抗体
  • NV11307 抗体

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) 抗体 精选生产商
您还需要查找其他产品吗?