DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) 蛋白 (DCUN1D1)

Part of an E3 ubiquitin ligase complex for neddylation. 再加上,我们可以发DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) 抗体 (76)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
DCUN1D1 54165 Q96GG9
DCUN1D1 114893 Q9QZ73
大鼠 DCUN1D1 DCUN1D1 310324  
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DCUN1D1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,
Mouse (Murine)

更多DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1)互动伙伴

Human DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) interaction partners

  1. DCUN1D1 is a target gene of miR (显示 MLXIP 蛋白)-195 in cervical cancer cells.

  2. the DCN1-UBC12 (显示 ube2m 蛋白) interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM

  3. SCRO has potential to become a new target for the treatment of PC

  4. We also found that both miR (显示 MLXIP 蛋白)-195 and DCUN1D1 siRNAs can inhibit cell invasion possibly through downregulating Matrix metalloproteinase-2 (MMP-2 (显示 MMP2 蛋白)) and Matrix metalloproteinase-9 (MMP-9 (显示 MMP9 蛋白)) at the post-transcriptional level, which can be attenuated by restoring the expression of DCUN1D1

  5. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

  6. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO

  7. Distinct preferences of UBC12 (显示 ube2m 蛋白) and UBE2F (显示 UBE2F 蛋白) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.

  8. substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (显示 CUL2 蛋白) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.

  9. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.

  10. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.

Mouse (Murine) DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) interaction partners

  1. Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 (显示 CUL3 蛋白) with Nedd8 (显示 NEDD8 蛋白), promoting Cul3 (显示 CUL3 蛋白)/Klhl21 (显示 KLHL21 蛋白) complex formation and localization of Cul3 (显示 CUL3 蛋白) during telophase. (Sccro = squamous cell carcinoma-related oncogene (显示 DCUN1D2 蛋白); Cul3 (显示 CUL3 蛋白) = cullin 3 (显示 CUL3 蛋白); Nedd8 (显示 NEDD8 蛋白) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 (显示 KLHL21 蛋白) = kelch-like protein 21 (显示 KLHL21 蛋白))

  2. SCCRO family members cooperatively regulate neddylation and cell proliferation.

  3. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

  4. in the nucleus, SCCRO enhances recruitment of Ubc12 (显示 ube2m 蛋白) to Cul1 (显示 CUL1 蛋白) to promote neddylation

  5. SCCRO promotes glioma formation and malignant progression.

  6. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

蛋白简介DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1)

蛋白简介

Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene names and symbols associated with DCUN1D1

  • DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (dcun1d1)
  • DCN1-like protein 1 (dcnl1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 L homeolog (dcun1d1.L)
  • defective in cullin neddylation 1 domain containing 1 (DCUN1D1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (Dcun1d1)
  • defective in cullin neddylation 1 domain containing 1 (Dcun1d1)
  • DCNL1 蛋白
  • DCUN1L1 蛋白
  • fd19a01 蛋白
  • pTes3 蛋白
  • Rp42 蛋白
  • SCCRO 蛋白
  • SCRO 蛋白
  • Tes3 蛋白
  • wu:fd19a01 蛋白
  • zgc:66414 蛋白

Protein level used designations for DCUN1D1

DCN1-like protein 1 , DCUN1 domain-containing protein 1 , RP42 homolog , defective in cullin neddylation protein 1-like protein 1 , squamous cell carcinoma related oncogene , squamous cell carcinoma-related oncogene , testis derived transcript 3 , testis-specific protein 3

GENE ID SPECIES
327232 Danio rerio
100301762 Oncorhynchus mykiss
414532 Xenopus laevis
54165 Homo sapiens
424963 Gallus gallus
606979 Canis lupus familiaris
539869 Bos taurus
114893 Mus musculus
310324 Rattus norvegicus
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