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Part of an E3 ubiquitin ligase complex for neddylation. 再加上，我们可以发DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) 抗体 (76) 和 和数多这个蛋白质的别的产品。
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DCUN1D1 is a target gene of miR (显示 MLXIP 蛋白)-195 in cervical cancer cells.
the DCN1-UBC12 (显示 ube2m 蛋白) interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM
SCRO has potential to become a new target for the treatment of PC
We also found that both miR (显示 MLXIP 蛋白)-195 and DCUN1D1 siRNAs can inhibit cell invasion possibly through downregulating Matrix metalloproteinase-2 (MMP-2 (显示 MMP2 蛋白)) and Matrix metalloproteinase-9 (MMP-9 (显示 MMP9 蛋白)) at the post-transcriptional level, which can be attenuated by restoring the expression of DCUN1D1
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO
Distinct preferences of UBC12 (显示 ube2m 蛋白) and UBE2F (显示 UBE2F 蛋白) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.
substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (显示 CUL2 蛋白) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.
a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.
Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 (显示 CUL3 蛋白) with Nedd8 (显示 NEDD8 蛋白), promoting Cul3 (显示 CUL3 蛋白)/Klhl21 (显示 KLHL21 蛋白) complex formation and localization of Cul3 (显示 CUL3 蛋白) during telophase. (Sccro = squamous cell carcinoma-related oncogene (显示 DCUN1D2 蛋白); Cul3 (显示 CUL3 蛋白) = cullin 3 (显示 CUL3 蛋白); Nedd8 (显示 NEDD8 蛋白) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 (显示 KLHL21 蛋白) = kelch-like protein 21 (显示 KLHL21 蛋白))
SCCRO family members cooperatively regulate neddylation and cell proliferation.
in the nucleus, SCCRO enhances recruitment of Ubc12 (显示 ube2m 蛋白) to Cul1 (显示 CUL1 蛋白) to promote neddylation
SCCRO promotes glioma formation and malignant progression.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
DCN1-like protein 1
, DCUN1 domain-containing protein 1
, RP42 homolog
, defective in cullin neddylation protein 1-like protein 1
, squamous cell carcinoma related oncogene
, squamous cell carcinoma-related oncogene
, testis derived transcript 3
, testis-specific protein 3