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CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007 [PubMed 17376772]).[supplied by OMIM, Mar 2008].. 再加上，我们可以发Cytoskeleton Associated Protein 2 抗体 (41) 和 和数多这个蛋白质的别的产品。
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High CKAP2 expression is associated with highgrade glioma.
High CKAP2 expression is associated with Ovarian Cancer.
Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.
The transcriptional activity of RHOA (显示 RHOA 蛋白), SEMA3B (显示 SEMA3B 蛋白), and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.
CKAP2 is involved in the maintenance of microtubule nucleation sites
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1 (显示 PSG1 蛋白), possibly by Cyclin A (显示 CCNA2 蛋白)/Cdk (显示 CDK4 蛋白) complex.
Findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical for kinase-substrate recognition and for regulation of the subcellular localization of TMAP during mitosis.
TMAP is limited to pre-anaphase stages and suggest that the multiple phosphorylation may not act in concert but serve diverse functions.
CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors
Data show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (显示 CDH1 蛋白) and that the KEN box motif near the N terminus is necessary for its destruction.
The results suggest that the phosphorylation of Cytoskeleton Associated Protein 2 (CKAP2) at T603 and possibly S608 phosphorylation sites by Cyclin Dependent Kinase 1 (CDK1 (显示 CDK1 蛋白)) during mitosis is essential for maintaining the number of centrosomes.
we found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells
These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability.
These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties
Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy.
The cellular functions of TMAP/CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis.
Our present findings demonstrate that TMAP/CKAP2 is essential for proper chromosome segregation and for maintaining genomic stability.
CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007
cytoskeleton-associated protein 2
, intracellular protein
, cytoskeleton associated protein 2
, cytoskeleton-associated protein 2-like
, CTCL tumor antigen se20-10
, tumor- and microtubule-associated protein
, tumor-associated microtubule-associated protein