Cytoskeleton Associated Protein 2 蛋白 (CKAP2)

CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007 [PubMed 17376772]).[supplied by OMIM, Mar 2008].. 再加上,我们可以发Cytoskeleton Associated Protein 2 抗体 (41)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CKAP2 26586 Q8WWK9
CKAP2 80986 Q3V1H1
大鼠 CKAP2 CKAP2 306575  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性 SDS-PAGE analysis of Mouse CKAP2 Protein. 100 μg Log in to see 11至18个工作日
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CKAP2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine) ,

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Human Cytoskeleton Associated Protein 2 (CKAP2) interaction partners

  1. High CKAP2 expression is associated with highgrade glioma.

  2. High CKAP2 expression is associated with Ovarian Cancer.

  3. Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.

  4. The transcriptional activity of RHOA (显示 RHOA 蛋白), SEMA3B (显示 SEMA3B 蛋白), and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.

  5. CKAP2 is involved in the maintenance of microtubule nucleation sites

  6. GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1 (显示 PSG1 蛋白), possibly by Cyclin A (显示 CCNA2 蛋白)/Cdk (显示 CDK4 蛋白) complex.

  7. Findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical for kinase-substrate recognition and for regulation of the subcellular localization of TMAP during mitosis.

  8. TMAP is limited to pre-anaphase stages and suggest that the multiple phosphorylation may not act in concert but serve diverse functions.

  9. CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors

  10. Data show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (显示 CDH1 蛋白) and that the KEN box motif near the N terminus is necessary for its destruction.

Mouse (Murine) Cytoskeleton Associated Protein 2 (CKAP2) interaction partners

  1. The results suggest that the phosphorylation of Cytoskeleton Associated Protein 2 (CKAP2) at T603 and possibly S608 phosphorylation sites by Cyclin Dependent Kinase 1 (CDK1 (显示 CDK1 蛋白)) during mitosis is essential for maintaining the number of centrosomes.

  2. we found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells

  3. These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability.

  4. These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties

  5. Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy.

  6. The cellular functions of TMAP/CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis.

  7. Our present findings demonstrate that TMAP/CKAP2 is essential for proper chromosome segregation and for maintaining genomic stability.

蛋白简介Cytoskeleton Associated Protein 2 (CKAP2)

蛋白简介

CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007

Gene names and symbols associated with CKAP2

  • cytoskeleton associated protein 2 (CKAP2)
  • cytoskeleton associated protein 2 (Ckap2)
  • AI461656 蛋白
  • AW228814 蛋白
  • LB1 蛋白
  • se20-10 蛋白
  • TMAP 蛋白

Protein level used designations for CKAP2

cytoskeleton-associated protein 2 , intracellular protein , cytoskeleton associated protein 2 , cytoskeleton-associated protein 2-like , CTCL tumor antigen se20-10 , tumor- and microtubule-associated protein , tumor-associated microtubule-associated protein

GENE ID SPECIES
100052303 Equus caballus
418882 Gallus gallus
100515274 Sus scrofa
26586 Homo sapiens
80986 Mus musculus
306575 Rattus norvegicus
515249 Bos taurus
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