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Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine.
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The highly conserved residue E227 acts as the catalytic base to accept the guanidinium proton transferred from creatine in UMTCK (显示 CKMT1B 抗体).
Mitochondrial creatine kinase (显示 CKMT2 抗体) CKMT1 (显示 CKMT1B 抗体) is necessary for survival of EVI1 (显示 MECOM 抗体)-expressing cells in subjects with EVI1 (显示 MECOM 抗体)-positive AML (显示 RUNX1 抗体).
LRRK2 can interact directly with uMtCK (显示 CKMT1B 抗体) to block its entry into mitochondria and its subsequent processing.
CKMT1 (显示 CKMT1B 抗体) is a key regulator of the permeability transition pore through a complex that is distinct from the classical permeability transition pore.
mitochondrial creatine kinase (显示 CKMT2 抗体) expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 (显示 ASB9 抗体) could be a negative regulator
The results indicated that uMtCK (显示 CKMT1B 抗体) expression is associated with a poor prognosis in breast cancer and might serve as a tumor marker.
Hypothalamic plasticity of neuropeptide Y (显示 NPY 抗体) is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
the knock-down of the mitochondrial creatine kinase (显示 CKMT2 抗体)-1 (CKMT1) by RNA interference causes the dissipation of the mitochondrial membrane potential
UbCKmit was expressed selectively in neurons and localized in their mitochondria in dendrites, cell bodies
Data suggest that amyloid precursor protein (显示 APP 抗体) may regulate cellular energy levels and mitochondrial function via a direct interaction and stabilization of ubiquitous mitochondrial creatine kinase.
Mt-CK(-/-) on a C57BL/6 background do not develop LV hypertrophy or dysfunction even up to 1 year, and this may be explained by a compensatory increase in MM-CK activity and mitochondrial volume
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase\\\\; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
, acidic-type mitochondrial creatine kinase
, creatine kinase U-type, mitochondrial
, creatine kinase, mitochondrial 1 (ubiquitous)
, ubiquitous mitochondrial creatine kinase
, creatine kinase, mitochondrial 1, ubiquitous
, Acidic-type mitochondrial creatine kinase
, Ubiquitous mitochondrial creatine kinase
, creatine kinase, mitochondrial 1B
, mitochondrial creatine kinase 1B