Complement Factor H-Related 5 蛋白 (CFHR5)

CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. 再加上,我们可以发Complement Factor H-Related 5 抗体 (79)Complement Factor H-Related 5 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CFHR5 81494 Q9BXR6
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CFHR5 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , ,
, ,

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Human Complement Factor H-Related 5 (CFHR5) interaction partners

  1. Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp (显示 KIAA1279 蛋白) involving multiple CFHR genes leading to a CFHR1 (显示 CFHR1 蛋白)-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy.

  2. Higher serum FHR-5 levels were associated with a lack of response to immunosuppression, the presence of endocapillary hypercellularity, and histology scores of IgA nephropathy severity.

  3. Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene

  4. Next-generation sequencing of the CFH (显示 CFH 蛋白) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (显示 CFH 蛋白)-related genes in the retina or RPE (显示 RPE 蛋白)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5]

  5. Studies indicate that complement factor H (显示 CFH 蛋白)-related proteins (FHR1 (显示 CFHR1 蛋白)-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  6. In this study, we identify pentraxin 3 (PTX3 (显示 PTX3 蛋白)) as a novel ligand of CFHR5

  7. At least two distinct intronic breakpoints within the CFHR5 gene can cause the same mutant CFHR5 protein and C3 glomerulopathy.

  8. A hybrid CFHR2 (显示 CFHR2 蛋白)-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H (显示 CFH 蛋白)-mediated convertase decay.

  9. Recent investigations in London and Cyprus culminated in the identification of another autosomal dominant condition that presents with microscopic haematuria because of heterozygous mutations in the CFHR5 gene--{review}

  10. A potentially pathogenic sequence variation was found in CFHR5 in the patients with atypical hemolytic uremic syndrome.

蛋白简介Complement Factor H-Related 5 (CFHR5)

蛋白简介

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Gene names and symbols associated with CFHR5

  • complement factor H related 5 (CFHR5)
  • CFHL5 蛋白
  • CFHR5D 蛋白
  • FHR-5 蛋白
  • FHR5 蛋白

Protein level used designations for CFHR5

complement factor H-related protein 5 , factor H-related protein 5

GENE ID SPECIES
81494 Homo sapiens
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