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CHN2 is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain.
Showing 10 out of 63 products:
Human Polyclonal CHN2 Primary Antibody for IHC (p), IHC - ABIN451800
Siliceo, Mérida: T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells. in The Journal of biological chemistry 2009
Human Polyclonal CHN2 Primary Antibody for ICC, IF - ABIN4297936
Alvi, McArt, Kelly, Fuchs, Alderdice, McCabe, Bingham, McGready, Tripathi, Emmert-Streib, Loughrey, McQuaid, Maxwell, Hamilton, Turkington, James, Wilson, Salto-Tellez: Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility. in Oncotarget 2015
our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.
Study demonstrates that Sema3F (显示 SEMA3F 抗体)-dependent inhibition of Rac1 by the Rac (显示 AKT1 抗体)-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
this study shows that serum chemerin (显示 RARRES2 抗体) is an independent risk factor of prognosis of non-small cell lung cancer patients
CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential
CHN2, ABCB1 (显示 ABCB1 抗体) and PPP1R9A (显示 PPP1R9A 抗体) expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.
genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied.
A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking.
genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
beta 2 chimerin has a role in rac (显示 AKT1 抗体)-GAP-dependent inhibition of breast cancer cell proliferation
Data demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac (显示 AKT1 抗体) regulation in T cells and suggest a functional role for this protein in Rac (显示 AKT1 抗体)-mediated cytoskeletal remodeling.
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, chimerin (chimaerin) 2
, Rho GTPase-activating protein 3
, beta chimaerin
, chimaerin 2
, rho-GTPase-activating protein 3
, rho GTPase-activating protein 3