Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008].
Tamburrino, Marchiani, Minetti, Forti, Muratori, Baldi: "The CatSper calcium channel in human sperm: relation with motility and involvement in progesterone-induced acrosome reaction." in: Human reproduction (Oxford, England), Vol. 29, Issue 3, pp. 418-28, (2014) (PubMed).