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The protein encoded by CDC14A is a member of the dual specificity protein tyrosine phosphatase family. 再加上，我们可以发CDC14A 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal CDC14A Primary Antibody for ICC, IF - ABIN4296773
Imtiaz, Belyantseva, Beirl, Fenollar-Ferrer, Bashir, Bukhari, Bouzid, Shaukat, Azaiez, Booth, Kahrizi, Najmabadi, Maqsood, Wilson, Fitzgerald, Tlili, Olszewski, Lund, Chaudhry, Rehman, Starost et al.: CDC14A phosphatase is essential for hearing and male fertility in mouse and human. ... in Human molecular genetics 1970
We demonstrate that XCdc14A upregulation prevents targeting of exocyst and SNARE (显示 NAPA 抗体) complexes to the midbody, both essential for abscission to occur.
Cdc14B (显示 CDC14B 抗体) knockout (Cdc14B (显示 CDC14B 抗体)(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy.
Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness.
Overexpressed miR (显示 MLXIP 抗体)-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR (显示 MLXIP 抗体)- 301a may be useful for osteosarcoma diagnosis and therapy.
These findings indicated that ZIPK (显示 DAPK3 抗体) may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A.
These data support the hypothesis that Cdc14A counteracts Cdk1 (显示 CDK1 抗体)-cyclin B1 (显示 CCNB1 抗体) activity through Wee1 (显示 WEE1 抗体) dephosphorylation.
CDC (显示 CDK1 抗体) (cell division cycle) 14A/B phosphatases associate with KIBRA (显示 WWC1 抗体), and CDK1 (显示 CDK1 抗体)-non-phosphorylatable KIBRA (显示 WWC1 抗体) has greatly reduced interaction with CDC14B (显示 CDC14B 抗体).
Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.
Cdc14A phosphatase prevents premature activation of Cdk1 (显示 CDK1 抗体) regulating Cdc25A (显示 CDC25A 抗体) and Cdc25B (显示 CDC25B 抗体) at the entry into mitosis.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
human Cdc14A phosphatase disrupts centrosome separation
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14A
, dual specificity protein phosphatase CDC14A
, CDC14 cell division cycle 14 homolog A
, cell division cycle 14 homolog A
, CDC14 homolog A
, CDC14 cell division cycle 14 homolog A (S. cerevisiae)
, dual specificity protein phosphatase CDC14A-like
, CDC10 (cell division cycle 10, S. cerevisiae, homolog)