CD47 (CD47) ELISA试剂盒

CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. 再加上,我们可以发CD47 抗体 (302)CD47 蛋白 (62)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
CD47 16423 Q61735
CD47 961 Q08722
CD47 29364 P97829
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Showing 5 out of 11 products:

产品编号 适用 灵敏度 范围 图像 规格 交付 价格 详细
0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests 15至18个工作日
大鼠 3.12 pg/mL 12.5-800 pg/mL Typical standard curve 96 Tests 15至18个工作日
小鼠 3.91 pg/mL n/a   96 Tests 15至18个工作日
  96 Tests 26至36个工作日
  480 Tests 2至3个工作日

适于 CD47 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) CD47 interaction partners

  1. Cd47 (-/-) mice exhibited depletion of natural killer (NK) precursors in bone marrow, consistent with the antiphagocytic function of Cd47. In contrast, antisense Cd47 knockdown or gene disruption resulted in a dose dependent accumulation of immature and mature NK cells in spleen. Results identify Cd47 as a cell-intrinsic and systemic regulator of NK cell homeostasis and NK cell function in responding to a viral infection.

  2. these results demonstrate that CD47-SIRPalpha signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs

  3. this study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis

  4. Herein, we reported a novel dual-targeting therapy for glioblastoma through simultaneous blockade of VEGF and CD47 signaling.

  5. Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma.

  6. These results establish that CD36 and CD47 both participate in mediating the actions of TSP-1 in osteoclasts and establish a physiologically relevant cross-talk in bone tissue between these two molecules.

  7. CD11c and its partner Itgb2 were required for DC capture of CD47-deficient cells. CD11b was not necessary for this process but could partially compensate in the absence of CD11c. Mice with DCs lacking Talin1, Itgb2, or CD11c were defective in supporting T-cell proliferation and differentiation induced by CD47-deficient cell associated antigen.

  8. this study shows that inhibition of IAP represses inflammatory status via nuclear factor-kappa B pathway in murine endometriosis lesions

  9. Our results support an intrinsic role of CD47 in ovarian cancer progression and immune evasion

  10. Mechanistic studies suggest a PKC-Syk-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.

  11. mice deficient in CD47 (CD47 Knockout) had significantly less brain neutrophil infiltration at 24h, upregulated VEGF expression in peri-lesion cortex at 7 and 14day

  12. TSP1 significantly accelerates replicative senescence and associated cell cycle arrest in a CD47-dependent manner.

  13. CD47, TSP1, and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  14. In pulmonary hypertension TSP1-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.

  15. thrombospondin-1 via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal.

  16. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  17. this study shows that CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis

  18. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  19. These results identify CD47 as an important regulator of LFA-1 and VLA-4 integrin-adhesive functions in T cell proliferation.

  20. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA interaction and Rac1/Akt activation.

Human CD47 interaction partners

  1. CD47 promotes the malignancy of colorectal cancer in association with EMT and enhances the stemness of cancer cells. All recurrent tumors highly expressed CD47 and CD44 and showed the epithelial-mesenchymal transition phenotype.

  2. PD-L1 expression correlated with CD47 expression.

  3. CD47-ligation induced cell death in T-acute lymphoblastic leukemia.

  4. CD47 and PD-L1 serve as critical innate and adaptive checkpoints, respectively, both of them are critical to the immune system. Therefore, we believe this dual-targeting strategy will provide insight into tumor immunotherapy for better tumor control.

  5. QPCTL is critical for pyroglutamate formation on CD47 at the SIRPalpha binding site shortly after biosynthesis.

  6. These results suggest that CD47 might be a useful predictor of poor prognosis and metastasis and a potential target for treating glioblastomas.

  7. cancer cell expression of SLAMF7 is not required for phagocytosis and, in contrast to CD47 expression, should not be used as selection criterion for CD47-targeted therapy.

  8. PD1/PDL1 and CD47 may be involved in the disease progression and prognosis of T-lymphoblastic lymphoma/leukemia

  9. this study shows that CD47 blockade inhibits tumor progression through promoting phagocytosis of tumor Cells by M2 polarized macrophages in endometrial cancer

  10. Therefore, the differential responses observed with CD47 blockade are due to autonomous activation of protective autophagy in normal tissue and enhancement immune cytotoxicity against cancer cells.

  11. results suggest that cancers can evolve SE to drive CD47 overexpression to escape immune surveillance

  12. overexpression of human CD200 in donor pigs could constitute a promising strategy for overcoming xenograft rejection.

  13. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity.

  14. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.

  15. Results show that the thrombospondin 1 (TSP1) and its receptor CD47 (CD47) axis selectively regulates NADPH oxidase 1 (Nox1) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.

  16. CD47 is overexpressed in primary non-small cell lung cancer (NSCLC) tissues and cell lines, suggesting that CD47 is a promising therapeutic target for NSCLC.

  17. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP-alpha) as self/non-self. Tissue factor pathway inhibitor (TFPI) is involved in the regulation of the coagulation pathway and is able to bind to another ligand of CD47, thrombospondin-1 (TSP-1).

  18. Blocking CD47 using antibodies could efficiently induce macrophage-mediated phagocytosis of tumor cells and treat cancers.

  19. High CD47 expression is not associated with Fibrolamellar Hepatocellular Carcinoma.

  20. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

Pig (Porcine) CD47 interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47-dependent manner

  2. Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.

Cow (Bovine) CD47 interaction partners

  1. temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis

CD47 抗原简介

Antigen Summary

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CD47 (CD47) ELISA试剂盒

  • CD47 antigen (Rh-related antigen, integrin-associated signal transducer) (Cd47) 抗体
  • CD47 molecule (CD47) 抗体
  • Cd47 molecule (Cd47) 抗体
  • 9130415E20Rik 抗体
  • AA407862 抗体
  • AI848868 抗体
  • AW108519 抗体
  • B430305P08Rik 抗体
  • CD47/IAP 抗体
  • IAP 抗体
  • Itgp 抗体
  • MER6 抗体
  • OA3 抗体

Protein level used designations for CD47 (CD47) ELISA试剂盒

Rh-related antigen , integrin-associated protein , leukocyte surface antigen CD47 , CD47 antigen (Rh-related antigen, integrin-associated signal transducer) , CD47 glycoprotein , antigen identified by monoclonal antibody 1D8 , antigenic surface determinant protein OA3 , integrin associated protein , integrin-associated signal transducer , CD47 antigen , IAP

16423 Mus musculus
961 Homo sapiens
478552 Canis lupus familiaris
397042 Sus scrofa
282661 Bos taurus
101111153 Ovis aries
29364 Rattus norvegicus
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