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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. 再加上，我们可以发PD-L1 抗体 (374) 和 PD-L1 蛋白 (87)和数多这个蛋白质的别的产品。
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
Programmed death-ligand 1 is expressed in a significant number of the uterine cervical carcinomas
PD-L1 expression is detectable in two distinct cell populations in the peripheral blood of lung cancer patients and is associated with worse survival.
Although hsa_circ_0020397 did not influence miR (显示 MLXIP ELISA试剂盒)-138 expression per se, has_circ_0020397 did inhibit miR (显示 MLXIP ELISA试剂盒)-138 activity, as examined via the expression of miR (显示 MLXIP ELISA试剂盒)-138 targets telomerase reverse transcriptase (TERT (显示 TERT ELISA试剂盒)) and programmed death-ligand 1 (PD-L1).
Our study demonstrates a cross-talk between PARPi and tumor-associated immunosuppression and provides evidence to support the combination of PARPi and PD-L1 or PD-1 (显示 PDCD1 ELISA试剂盒) immune checkpoint blockade as a potential therapeutic approach to treat breast cancer
obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR (显示 IFNGR1 ELISA试剂盒) variants were added
PIPKIgamma promotes the transcription of the PD-L1 gene by activating the NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway in these cells. These results demonstrate that PIPKIgamma-dependent expression of PD-L1 is likely important for the progression of triple negative breast cancer.
Therefore, in Crohn's disease intestinal antigen taken up by lymphoid patch APCs (显示 APCS ELISA试剂盒) will be presented without PD-L1 induced tolerogenic signalling, perhaps initiating disease.
results indicate that PD-L1-expressing dysplastic epithelial and recruited subepithelial cells in oral precancerous legions may evade the host immune system, and that the inhibition of PD-1 (显示 PDCD1 ELISA试剂盒)/PD-L1 pathway may potentially prevent malignant transformation of oral precancerous legions as well as can treat advanced cancers
PD-L1 expression was apparent in 10.4% of LCNEC and 5.8% of SCLC tumors, and was not observed in carcinoid tumors.
Our findings indicate that PD-L1 expression is a promising biomarker for the prognosis of breast cancer, and may be helpful to clinicians aiming to select the appropriate immunotherapy for breast cancer.
In estrogen receptor (显示 ESR1 ELISA试剂盒) negative breast cancer cells targeting of IL-17A (显示 IL17A ELISA试剂盒) inhibited PDL1 expression in the tumor microenvironment, decreasing the percentage of Treg cells in tumor-infiltrating lymphocytes, and promoting CD4 (显示 CD4 ELISA试剂盒)+ and CD8 (显示 CD8A ELISA试剂盒)+ T cells to secrete interferon gamma (显示 IFNG ELISA试剂盒).
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8 (显示 CD8A ELISA试剂盒)+ T Cells co-expressing PD-1 (显示 PDCD1 ELISA试剂盒) and LAG-3 (显示 LAG3 ELISA试剂盒) inhibitory receptors.
Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions.
Studied the possible role of PD-L1 on malignant melanoma initiating cells (MMICs). Found blocking of PD-L1 in melanoma cell lines impaired tumorsphere formation and induced the apoptosis. Also, blocking PD-L1 inhibited tumor growth in vivo.
B7-H1 induction in keratinocytes may play a crucial role in the protection from CD4 (显示 CD4 ELISA试剂盒)+ T cell-mediated tissue inflammation by exogenous antigens delivered from the mucosal surface in oral cavity
Interferon (显示 IFNA ELISA试剂盒)-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.
RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin (显示 ZFP36 ELISA试剂盒).
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (显示 MLXIP ELISA试剂盒)-155, Pdcd1 (显示 PDCD1 ELISA试剂盒), Pdcd1l1, and Ctla4 (显示 CTLA4 ELISA试剂盒) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 (显示 PDCD1 ELISA试剂盒) = programmed cell death 1 (显示 PDCD1 ELISA试剂盒) protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 (显示 CTLA4 ELISA试剂盒) = cytotoxic T-lymphocyte-associated protein 4 (显示 CTLA4 ELISA试剂盒)]
Expression of LAP/TGF-beta1 (显示 TGFB1 ELISA试剂盒), CD80 (显示 CD80 ELISA试剂盒), CD86 (显示 CD86 ELISA试剂盒) and PD-L1 is significantly increased in tumor-infiltrating B cells (TIL (显示 TLR1 ELISA试剂盒)-B) relative to splenic B cells. LAP/TGF-beta1 (显示 TGFB1 ELISA试剂盒) expression on TIL (显示 TLR1 ELISA试剂盒)-B progressively increased from 5.4+/-1.7% on day 8 to 43.1+/-6.1% by day 21 post tumor implantation.
spleen-derived IFN-gamma (显示 IFNG ELISA试剂盒) induces generation of PD-L1(+)-suppressive neutrophils.
This study provides novel information for the understanding of signalling through PD-L1.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (显示 PDCD1 ELISA试剂盒)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (显示 PDCD1LG2 ELISA试剂盒) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
B7 homolog 1
, CD274 antigen
, PDCD1 ligand 1
, programmed cell death 1 ligand 1
, programmed death ligand 1
, CD274 molecule
, programmed cell death ligand 1