anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) 抗体

The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). 再加上,我们可以发BAP1 蛋白 (7)BAP1 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
BAP1 104416 Q99PU7
BAP1 8314 Q92560
BAP1 306257 D3ZHS6
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antibodies-online.cn销售最多的anti-BAP1 抗体

Showing 10 out of 127 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
小鼠 非结合性 IF, WB 0.1 mg Log in to see 6至8个工作日
非结合性 IHC (p), WB Western blot analysis of BAP1 Antibody (N-term) (ABIN388948) in mouse testis lysates (35 µg/lane). BAP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
小鼠 非结合性 FACS, WB Detection of BAP1 in HeLa WCE using ABIN258775 (2ug/ml). Flow Cytometry: BAP1 Antibody (1G8) [ABIN2587751] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HEK-293 (B) cells using BAP1 antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used. 0.1 mL Log in to see 7至9个工作日
非结合性 WB The anti-BAP1 Pab (ABIN388949) is used in Western blot to detect BAP1 in SK-BR-3 cell lysate. 400 μL Log in to see 10至11个工作日
小鼠 非结合性 WB Anti-BAP1 antibody (monoclonal), Western blotting Lane: MCF-7 Cell Lysate 100 μg Log in to see 4至6个工作日
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
非结合性 IC, IF, IHC, WB Immunofluorescent analysis of BAP1 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of BAP1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL Log in to see 13至14个工作日
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat testis labeled with Rabbit Anti Phospho-BAP1(Ser592) Polyclonal Antibody, Unconjugated (ABIN683413) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human breast carcinoma labeled with Rabbit Anti Phospho-BAP1(Ser592) Polyclonal Antibody, Unconjugated (ABIN683413) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日

通过反应活性、应用领域、克隆类型和共轭标记 BAP1 抗体

特性 应用范围 宿主 克隆类型 标记
Mouse (Murine) ,
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Rat (Rattus) , ,

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引用最多的anti-BAP1 抗体

  1. Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775 : Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010 (PubMed)

  2. Human Polyclonal BAP1 Primary Antibody for IHC (p), WB - ABIN388948 : Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011 (PubMed)


Mouse (Murine) BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. Bap1 as a metabolic regulator in liver and pancreas.

  2. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure

  3. BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.

  4. Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.

  5. INO80 (显示 INO80 抗体) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells

  6. Both Vhl (显示 VHL 抗体) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (显示 VHL 抗体) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (显示 VHL 抗体) in the kidney.

  7. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  8. Cx32 (显示 GJB1 抗体) expression is in part related to induction of tight junctions through modulation of Magi1 (显示 CNKSR3 抗体) expression in an immortalized hepatic cell line.

  9. ARIP1 (显示 MAGI2 抗体) and ARIP2 (显示 SYNJ2BP 抗体) are co-expressed in some nerve cells and their biological activities are distinct.

  10. results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (显示 HCFC1 抗体) and OGT (显示 OGT 抗体) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm

Human BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. study reports germline mutations of the BAP1 (显示 RNF2 抗体) gene in a sample of 1977 melanoma patients and 754 controls; sequencing revealed 30 BAP1 (显示 RNF2 抗体) variants in total, of which 27 were rare; of the 27 rare variants, 22 were present in cases (18 missense, 1 splice acceptor, 1 frameshift and 2 near splice regions) and 5 in controls (all missense)

  2. A deleterious mutation of BAP1 (显示 RNF2 抗体) was confirmed in 12/17 melanocytic BAP1 (显示 RNF2 抗体)-associated intradermal tumors cases.

  3. Although there have been reports of sarcomas and meningiomas in patients affected with BAP1 (显示 RNF2 抗体) mutations, to our knowledge malignant peripheral nerve sheath tumors in this patient population have not been previously reported. We report a case of malignant peripheral nerve sheath tumor in a patient affected by a BAP1 (显示 RNF2 抗体) mutation.

  4. Low BAP1 (显示 RNF2 抗体) expression is associated with lung cancer progression.

  5. Study shows that the tumor suppressor gene breast cancer [BRCA]1-associated protein 1 (BAP1 (显示 RNF2 抗体)) is inactivated in 6 high-grade, rhabdoid meningiomas. In addition to patients with somatic BAP1 (显示 RNF2 抗体) loss, 2 patients carried germline mutations, indicating that such meningiomas can arise as part of the BAP1 (显示 RNF2 抗体) cancer predisposition syndrome.

  6. Nine of the 32 (28.1%) iCCA (显示 PRRT2 抗体) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (显示 RNF2 抗体) mutations, two each (6.3%) of CACNA2D3 (显示 CACNA2D3 抗体) and RASSF1 (显示 RASSF1 抗体) mutations, and one each (3.1%) of ATG7 (显示 ATG7 抗体) and PLCD1 (显示 PLCD1 抗体) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.

  7. BAP1 (显示 RNF2 抗体) mutation, Copy Number Loss, and/or Loss of Protein Expression is associated with Malignant Peritoneal Mesotheliomas.

  8. BAP1 (显示 RNF2 抗体) regulates IP3R3 (显示 ITPR3 抗体)-mediated Ca(2 (显示 CA2 抗体)+) flux to mitochondria suppressing cell transformation

  9. Loss of BAP1 (显示 RNF2 抗体) expression is associated with lung adenocarcinoma.

  10. Our data confirm the established role of BAP1 (显示 RNF2 抗体) as a tumor suppressor protein (显示 TP53 抗体) and is the first report where BAP1 (显示 RNF2 抗体) has been studied in pT1 (显示 ZNF77 抗体) clear cell renal cell carcinomas

BAP1 抗原简介


The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Gene names and symbols associated with BAP1

  • Brca1 associated protein 1 (Bap1) 抗体
  • BRCA1 associated protein 1 (BAP1) 抗体
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (bap1) 抗体
  • BRCA1 associated protein 1 L homeolog (bap1.L) 抗体
  • membrane associated guanylate kinase, WW and PDZ domain containing 1 (Magi1) 抗体
  • 2300006C11Rik 抗体
  • AA989761 抗体
  • AIP3 抗体
  • AW553466 抗体
  • Baiap1 抗体
  • BAIAP3 抗体
  • BAP1 抗体
  • Gukmi1 抗体
  • hucep-6 抗体
  • hucep-13 抗体
  • Magi-1 抗体
  • MAGI1c 抗体
  • mKIAA0272 抗体
  • mKIAA4129 抗体
  • si:dkey-42i9.9 抗体
  • TNRC19 抗体
  • uch-x4 抗体
  • uchl2 抗体
  • WWP3 抗体

Protein level used designations for BAP1

BRCA1-associated protein 1 , ubiquitin C-terminal hydrolase X4 , ubiquitin carboxyl-terminal hydrolase BAP1 , cerebral protein 6 , cerebral protein-13 , Brca1 associated protein 1 , BAI1-associated protein 3 , ubiquitin carboxy-terminal hydrolase , BAI1-associated protein 1 , BAP-1 , guanylate kinase membrane-associated inverted 1 , membrane-associated guanylate kinase inverted 1 , membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

104416 Mus musculus
8314 Homo sapiens
484737 Canis lupus familiaris
306257 Rattus norvegicus
100124510 Bos taurus
415944 Gallus gallus
558885 Danio rerio
734438 Xenopus laevis
14924 Mus musculus
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