BRSK2 抗体
(BR serine/threonine Kinase 2 (BRSK2))
Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.
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Latest Publications for our BRSK2 抗体
: "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis." in: Journal of neuroimmunology, Vol. 170, Issue 1-2, pp. 186-90, (2005) (PubMed).: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).
: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).
: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).
: "The protein kinase complement of the human genome." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1912-34, (2002) (PubMed).
Aliases for BRSK2 抗体
BR serine/threonine kinase 2 (BRSK2) 抗体BR serine/threonine kinase 2 (Brsk2) 抗体
4833424K13Rik 抗体
BRSK2 抗体
C11orf7 抗体
PEN11B 抗体
SAD-A 抗体
SAD1 抗体
SADA 抗体
STK29 抗体
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