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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. 再加上，我们可以发BCOR 抗体 (69) 和 BCOR 蛋白 (7)和数多这个蛋白质的别的产品。
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BCOR-ITD was positively detected in the cfDNA of two cases, both of which were later diagnosed as CCSK based on histological feature of the resected tumor specimen, while it was not detected for a normal control and a patient diagnosed with Wilms' tumor.
Multivariate analysis demonstrated that BCOR mutations were an independent unfavorable prognostic factor (P = 0.0038, P = 0.0463) for both OS and RFS.
BCOR mutation is associated with tooth agenesis.
The majority of the cases of clear cell sarcoma of the kidney in our cohort had BCOR internal tandem duplications
BCOR was negative in all ewing sarcoma family of tumors
BCOR immunohistochemical staining is a highly sensitive marker for YWHAE (显示 YWHAE ELISA试剂盒)-NUTM2 high-grade endometrial stromal sarcoma with both classic and unusual morphology and identifies a subset of high-grade endometrial stromal sarcoma with BCOR alterations, including BCOR rearrangement and internal tandem duplication.
the frequent BCOR mutations and the absence of alterations in genes regulating the NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway (triple-negative for KLF2 (显示 KLF2 ELISA试剂盒), TNFAIP3 (显示 TNFAIP3 ELISA试剂盒) and MYD88 (显示 MYD88 ELISA试剂盒) mutations) or the absence of a BRAF (显示 BRAF ELISA试剂盒) mutation appear to delineate a specific genetic pattern of SDRPL, which is distinct from that already identified in SMZL, HCL or HCL-v.
BCOR internal tandem duplication and/or nuclear immunoreactivity for BCOR or BCL6 (显示 BCL6 ELISA试剂盒) can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.
Case Report: altered BCOR expression and homogeneous coactivation of both the SHH (显示 SHH ELISA试剂盒) and WNT (显示 WNT2 ELISA试剂盒) signaling pathways, and suggest potential novel therapeutic approaches for patients with a high grade neuroepithelial tumor of the central nervous system with BCOR alteration diagnosis.
Immunohistochemistry for either CCNB3 or BCOR is not completely sensitive and specific in undifferentiated sarcoma with BCOR-CCNB3 fusion.
Genomic characterization of Emu-Myc (显示 MYC ELISA试剂盒) mouse lymphomas identifies Bcor as a Myc (显示 MYC ELISA试剂盒) cooperative tumor-suppressor gene.
results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (显示 IRF8 ELISA试剂盒) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B complex by Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL-6 interacting corepressor
, BCL6 co-repressor
, Bcl6 interacting corepressor