(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F))
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Zhou, Han, Dang, Wang, Zheng: "A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR." in: Retrovirology, Vol. 6, pp. 31, (2009) (PubMed).
Han, Wang, Dang, Zheng: "APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication." in: PLoS pathogens, Vol. 4, Issue 7, pp. e1000095, (2008) (PubMed).