anti-Angiopoietin-Like 2 (ANGPTL2) 抗体

Human Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. ANGPTL2 is a biomarker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT.

2. ANGPTL2 was positively associated with aortic stiffness after kidney transplantation.

3. Serum ANGPTL2 levels were significantly increased in non-small cell lung carcinoma patients, which could serve as a novel potential diagnostic and prognostic biomarker for NSCLC.

4. Results reveal a novel cascade comprising sequential P. gingivalis lipopolysaccharide --> ANGPTL2 --> integrin alpha5beta1 --> inflammatory cytokine induction, which might be responsible for inducing potent periodontal disorganization activity in gingival epithelial cells. Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemi...

5. In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE.

6. Elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation.

7. Increased ANGPTL2 expression contributes to proliferation and invasion of gastric cancer cells.

8. Aberrant expression of ANGPTL2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome.

9. Reduced leukocyte DNA methylation (显示 HELLS 抗体) in the promoter region of ANGPTL2 is associated with the pro-inflammatory environment that characterizes patients with post-ACS (显示 PLA2G15 抗体) differently from age-matched healthy controls. Methylation of different CpGs in ANGPTL2 gene may prove to be a reliable biomarker of coronary disease

10. At 11-13 weeks in pregnancies that develop GDM, the serum concentration of ANGPTL2 is increased, and it can be combined with maternal factors to provide effective early screening for GDM.

Mouse (Murine) Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine.

2. we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke.

3. Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung.

4. Angptl2 regulates not only adipose tissue metabolism but also bone metabolism

5. findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection.

6. Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration.

7. ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin (显示 INS 抗体) resistance.

8. Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes.

9. In angptl2 knockdown mice, ACh (显示 FGFR3 抗体)-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice.

10. knockdown of angptl2 may be protective against ANG II (显示 AGT 抗体)-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress.

Zebrafish Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch (显示 NOTCH1 抗体) receptor.

2. developmental expression of Angptl1 (显示 ANGPTL1 抗体), 2 and 6 in zebrafish