anti-Angiopoietin-Like 2 (ANGPTL2) 抗体

Human Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. examination of the potential sources of circulating ANGPTL2 and its common pathological properties associated with various chronic inflammatory diseases (review).

2. Results showed that ANGPTL2 was highly expressed in glioma tissues and cell lines. Knockdown of ANGPTL2 reduced the proliferative and invasive abilities of glioma cells.

3. REVIEW: ANGPTL2 autocrine/paracrine signaling is a new factor in accelerating heart disease development in the aging. Here, we focus on current topics relevant to ANGPTL2 function in heart disease.

4. ANGPTL2 is a biomarker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT.

5. ANGPTL2 was positively associated with aortic stiffness after kidney transplantation.

6. Serum ANGPTL2 levels were significantly increased in non-small cell lung carcinoma patients, which could serve as a novel potential diagnostic and prognostic biomarker for NSCLC.

7. Results reveal a novel cascade comprising sequential P. gingivalis lipopolysaccharide --> ANGPTL2 --> integrin alpha5beta1 --> inflammatory cytokine induction, which might be responsible for inducing potent periodontal disorganization activity in gingival epithelial cells. Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemi...

8. In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE.

9. Elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation.

10. Increased ANGPTL2 expression contributes to proliferation and invasion of gastric cancer cells.

Mouse (Murine) Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine.

2. we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke.

3. Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung.

4. Angptl2 regulates not only adipose tissue metabolism but also bone metabolism

5. findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection.

6. Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration.

7. ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin (显示 INS 抗体) resistance.

8. Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes.

9. In angptl2 knockdown mice, ACh (显示 FGFR3 抗体)-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice.

10. knockdown of angptl2 may be protective against ANG II (显示 AGT 抗体)-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress.

Zebrafish Angiopoietin-Like 2 (ANGPTL2) interaction partners

1. Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch (显示 NOTCH1 抗体) receptor.

2. developmental expression of Angptl1 (显示 ANGPTL1 抗体), 2 and 6 in zebrafish