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The protein encoded by AMOTL1 is a peripheral membrane protein that is a component of tight junctions or TJs.
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Cow (Bovine) Polyclonal AMOTL1 Primary Antibody for WB - ABIN2775636
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005
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HECW2 (显示 HECW2 抗体), a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT (显示 AMOT 抗体)-like 1 (AMOTL1) stability.
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin (显示 NF2 抗体).
phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP (显示 YAP1 抗体) inhibition.
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (显示 CREBBP 抗体), CBFA2T3 (显示 CBFA2T3 抗体), AMOTL1, FAT4 (显示 FAT4 抗体), FBXO11 (显示 FBXO11 抗体), PLA2G4D (显示 PLA2G4D 抗体), TRRAP (显示 TRRAP 抗体) and USH2A (显示 USH2A 抗体).
miR (显示 MLXIP 抗体)-124 binds AmotL1 3'UTR (显示 UTS2R 抗体) and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells.
Scaffold proteins angiomotin (Amot (显示 AMOT 抗体)) and angiomotin (显示 AMOT 抗体)-related AmotL1 and AmotL2 (显示 AMOTL2 抗体) were recently identified as negative regulators of YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) by preventing their nuclear translocation.
These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs.
AmotL1 and ZO-2 (显示 TJP2 抗体) are two candidates that could be harnessed to control the oncogenic function of YAP (显示 YAP1 抗体).
By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein (显示 MYOM2 抗体) of parainfluenza virus 5 (PIV5).
The angiomotin-like 1 is involved in actin-cytoskeleton-based processes, in part, via its interaction with a p80-angiomotin-containing complex and the actin cytoskeleton
Amot (显示 AMOT 抗体) and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot (显示 AMOT 抗体) appears to control the cell polarity and AmotL1 affects the stability of cell-cell junctions.
The authors propose that AmotL1 is an essential effector of the N-cadherin (显示 CDH2 抗体) mediated endothelial/pericyte junctional complex.
Amot (显示 AMOT 抗体), Amotl1, and Amotl2 (显示 AMOTL2 抗体) are differentially expressed in uterine cells during the peri (显示 POSTN 抗体)-implantation period.
Data show that MUPP1 (显示 MPDZ 抗体) interacts with angiomotin (Amot (显示 AMOT 抗体)), JEAP/Amot (显示 AMOT 抗体)-like 1 and MASCOT/Amot (显示 AMOT 抗体)-like 2, and that all the Amot (显示 AMOT 抗体)/JEAP family proteins also interacted with Patj (显示 INADL 抗体), a close relative of MUPP1 (显示 MPDZ 抗体).
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.
angiomotin like 1
, angiomotin-like protein 1-like
, angiomotin-like protein 1
, junction-enriched and associated protein
, junction-enriched and -associated protein