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Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. 再加上，我们可以发Anaphase Promoting Complex Subunit 15 蛋白 (5) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal ANAPC15 Primary Antibody for ICC, IF - ABIN4285964
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
cryo-EM structure of an APC (显示 APC 抗体)/C-Cdh1 (显示 CDH1 抗体) complex with Apc1 (显示 SLC25A24 抗体)(WD40 (显示 DCAF12L2 抗体)) deleted showed that the mutant APC (显示 APC 抗体)/C is locked into an inactive conformation in which the UbcH10 (显示 UBE2C 抗体)-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible
Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 (显示 CDC20 抗体) and mitotic checkpoint (显示 BUB3 抗体) protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
APC15 is required for anaphase-promoting complex/cyclosome-bound mitotic checkpoint (显示 BUB3 抗体) complex-dependent CDC20 (显示 CDC20 抗体) autoubiquitylation and degradation and for timely anaphase initiation.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
anaphase-promoting complex subunit 15
, protein HSPC020 homolog