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The protein encoded by AP3D1 is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures.
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Human Polyclonal AP3D1 Primary Antibody for ELISA, WB - ABIN129555
Concepcion, Flores-Garcuia, Hamilton: Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. in PLoS genetics 2009
A genome-wide association study identifies PLCL2 (显示 PLCL2 抗体) and AP3D1-DOT1L (显示 DOT1L 抗体)-SF3A2 (显示 SF3A2 抗体) as new susceptibility loci for myocardial infarction in Japanese
Unexpectedly, no evidence of binding between the N-terminal matrix (MA) domain of HIV-1 Gag and the cellular Adaptor Protein AP-3 (AP-3delta) was observed in these in vitro experiments.
The matrix region of HIV-1 Gag interacts directly with the delta subunit of the AP-3 complex, and that this interaction plays an important functional role in particle assembly
AP-3 and AP-1 (显示 FOSB 抗体) function in partially redundant pathways to transfer tyrosinase (显示 TYR 抗体) from distinct endosomal subdomains to melanosomes and that the AP-3 pathway ensures that tyrosinase (显示 TYR 抗体) averts entrapment on internal membranes of forming multivesicular bodies
The studies demonstrate a role for AP-3 in HIV replication in a tetraspanin-rich compartment in dendritic cells (DC) and contribute to the elucidation of the trafficking pathways required for DC-T cell transfer of HIV-1 infection.
The linker of the delta-adaptin subunit of AP3 (显示 AP3B1 抗体) binds the VAMP7 (显示 VAMP7 抗体) longin domain and determines the structure of their complex.
This study demonstrated that distinct brain regions differentially regulate AP-3-dependent synaptic vesicle biogenesis.
Assembly and function of AP-3 complexes in cells expressing mutant subunits
Data suggest that adaptor-related protein complex 3 delta could be involved in the regulation of progenitor cell competence and the eventual ratio of resulting differentiated cells.
A null mutation in Ap3d in the mouse results in the mouse mutant "mocha" (mh). In addition to coat and eye color dilution and platelet storage pool deficiency, mocha mice have neurological impairment and are hyperactive.
The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
AP-3 complex subunit delta-1
, AP-3 complex delta subunit, partial CDS
, AP-3 complex subunit delta
, adapter-related protein complex 3 subunit delta-1
, adaptin, delta
, delta adaptin
, delta-adaptin, partial CDS
, subunit of putative vesicle coat adaptor complex AP-3
, adaptor-related protein complex 3, delta subunit
, adaptor-related protein complex AP-3, delta subunit
, bovine leukemia virus cell receptor
, bovine leukemia virus, cell receptor