anti-Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) 抗体

AP3B1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes.

列出全部抗体 基因 基因ID UniProt
 AP3B1 AP3B1 8546 O00203
小鼠 AP3B1 AP3B1 11774 Q9Z1T1
大鼠 AP3B1 AP3B1 309969  
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antibodies-online.cn销售最多的anti-AP3B1 抗体

Showing 10 out of 42 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-Ap3b1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Rat Liver 100 μL Log in to see 2至3个工作日
非结合性 WB Western Blot: AP3B1 Antibody [NBP1-33723] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8至11个工作日
非结合性 WB 100 μL Log in to see 7至9个工作日
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged AP3B1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8至11个工作日
山羊 非结合性 IHC (p) Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6至8个工作日
非结合性 ELISA, WB The AP3 Antibody is used in Western blot to detect AP3 in HeLa cell lysates. 0.1 mg Log in to see 2至6个工作日
大鼠 非结合性 WB Western Blot: AP3B1 Antibody [NBP1-68927] - Rat Liver lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8至11个工作日
非结合性 IHC, IHC (p) Immunohistochemistry: AP3B1 Antibody [NBP1-89228] - Staining of human stomach shows moderate cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: AP3B1 Antibody  - Staining of human cell line HeLa shows localization to nucleoplasm & the Golgi apparatus. Antibody staining is shown in green. 0.1 mL Log in to see 10至13个工作日
非结合性 IHC, WB Western blot analysis of extracts of various cells, using AP3B1 antibody. 100 μL Log in to see 16 Days
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged AP3B1 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 11至12个工作日

引用最多的anti-AP3B1 抗体

  1. Cow (Bovine) Polyclonal AP3B1 Primary Antibody for WB - ABIN2778057 : Kuwahara, Inoue, DAgati, Fujimoto, Eguchi, Saha, Wolozin, Iwatsubo, Abeliovich: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. in Scientific reports 2016 (PubMed)


Human Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) interaction partners

  1. point mutation c.2702C>G in exon 23 of the AP3B1 gene caused deletion of 112 bp in the mRNA in two siblings. This mutation activates a cryptic donor splice site that overrules the wild-type donor splice site of this exon. Three other novel mutations in AP3B1 were identified, that is, a nonsense mutation c.716G>A (p.Trp239Ter), a 1-bp and a 4-bp deletion c.177delA and c.1839_1842delTAGA, respectively

  2. Synergistic defects of UNC13D (显示 UNC13D 抗体) and AP3B1 leading to adult hemophagocytic lymphohistiocytosis.

  3. Using a co-affinity purification strategy, authors have identified the beta subunit (显示 POLG 抗体) of the AP-3 adapter protein (显示 TOLLIP 抗体) complex, AP3B1, as a binding partner for the M proteins of the zoonotic paramyxoviruses Nipah virus and Hendra virus.

  4. Data indicate that RUN and FYVE domain protein Rabip4'(RUFY1 (显示 RUFY1 抗体)) interacts specifically and directly with adaptor protein complex AP-3.

  5. The study provides a description of two unrelated individuals with Hermansky Pudlak syndrome type 2 associated with novel mutations in AP3B1.

  6. diphosphoinositol pentakisphosphate-mediated pyrophosphorylation of AP3B1 modulates the interaction with Kif3A (显示 KIF3A 抗体) and, as a consequence, affects the release of HIV-1 virus-like particles.

  7. Two nonsense mutations in ADTB3A, C1578T (R-->X) and G2028T (E-->X), result in lack of ADTB3A mRNA and beta3A (显示 BHLHE22 抗体) protein production and a severe, G-CSF (显示 CSF3 抗体)-responsive neutropenia in addition to oculocutaneous albinism and platelet storage pool deficiency.

  8. Description of mutations in HPS (显示 HPS1 抗体) genes that cause Hermansky-Pudlak syndrome (review)

  9. We defined a homozygous genomic deletion in AP3B1, the gene encoding the beta chain of the adaptor protein-3 (AP-3) complex. The mutation leads to in-frame skipping of exon 15 and thus perturbs proper assembly of the heterotetrameric AP-3 complex.

  10. A novel homozygous mutation in AP3B1 was detected in a 2-year-old patient with oculocutaneous albinism and immunodeficiency with Hermansky-Pudlak syndrome type II and eventual acute fatal hemophagocytic lymphohistiocytosis.

Mouse (Murine) Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) interaction partners

  1. HIV-2 particle release was dependent on the adaptor protein complex AP-3 and the newly identified AP-5 complex, but much less so on AP-1 (显示 JUN 抗体).

  2. Data show that cytokine activation as a result of toll-like receptor 2 (TLR2) stimulation occurs at different intracellular locations and is mediated by the phagosomal trafficking molecule adaptor protein-3 (AP-3).

  3. Our study indicates that Ap3b1 gene play distinct roles in melanin production and tyrosinase (显示 TYR 抗体) distribution compared with Hps1 gene.

  4. we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway.

  5. Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.

  6. The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 (显示 PLDN 抗体) and BLOC-2 (显示 HPS6 抗体) are essential for plasmacytoid dendritic cells signaling through TLR7 (显示 TLR7 抗体) and TLR9 (显示 TLR9 抗体).

  7. TLR9 (显示 TLR9 抗体) signals leading to activation of IFN I, require TLR9 (显示 TLR9 抗体) trafficking from endosomes to lysosome-related organelle; adapter protein (显示 GRB10 抗体)-3 (显示 HSPB3 抗体) identified as protein complex responsible for trafficking of TLR9 (显示 TLR9 抗体) to this subcellular compartment

  8. AP-3 mediates the intracellular trafficking of CD1d (显示 CD1D 抗体) to lysosomes for sampling of lipid antigens (Ags (显示 GLA 抗体)) involved in self-Ag presentation and thymocyte-positive selection.

  9. AP-3 requirement is a particular attribute of the CD1d (显示 CD1D 抗体) pathway in mice and that, although MHC class II molecules and CD1d (显示 CD1D 抗体) are both found in late endosomes or lysosomes, different pathways mediate their intracellular trafficking

  10. AP-3B (显示 AP3M2 抗体) plays a critical role in the normal formation and function of a subset of synaptic vesicles

AP3B1 抗原简介


This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with AP3B1

  • adaptor related protein complex 3 beta 1 subunit L homeolog (ap3b1.L) 抗体
  • adaptor-related protein complex 3, beta 1 subunit a (ap3b1a) 抗体
  • adaptor related protein complex 3 beta 1 subunit (AP3B1) 抗体
  • adaptor-related protein complex 3, beta 1 subunit (Ap3b1) 抗体
  • ADTB3 抗体
  • ADTB3A 抗体
  • AP-3 抗体
  • AP3B1 抗体
  • AU015684 抗体
  • beta3A 抗体
  • C78395 抗体
  • cb964 抗体
  • HPS 抗体
  • Hps2 抗体
  • pe 抗体
  • pearl 抗体
  • rim2 抗体

Protein level used designations for AP3B1

adaptor-related protein complex 3, beta 1 subunit , AP-3 complex subunit beta-1 , adaptor-related protein complex 3, beta-1 subunit , AP-3 complex subunit beta-1-like , AP-3 complex beta-3A subunit , adaptor protein complex AP-3 subunit beta-1 , beta-3A-adaptin , clathrin assembly protein complex 3 beta-1 large chain , adapter-related protein complex 3 subunit beta-1 , adaptor protein complex AP-3 beta-1 subunit , adaptor-related protein complex AP-3, beta 1 subunit , beta3A-adaptin , recombination induced mutation 2 , adaptor-related protein complex AP3 beta 1 subunit

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