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The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. 再加上，我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal APPL2 Primary Antibody for IF, WB - ABIN527414
Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011
Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 (显示 APLP2 抗体) gene provides a putative colorectal neoplasm progression index.
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
ATM (显示 ATM 抗体) is the central modulator of APPL (显示 APPL1 抗体)-mediated effects on radiosensitivity and DNA repair.
It concludes that APPL2 (显示 APLP2 抗体)(PH) binding to BAR domain and Reptin (显示 RUVBL2 抗体) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (显示 RUVBL2 抗体).
C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.
Data indicate that a high level of APPL2 (显示 APLP2 抗体) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.
analysis of APPL1 (显示 APPL1 抗体) and APPL2 (显示 APLP2 抗体) proteins and their interaction with Rab (显示 HRB 抗体)
Genetic variation(s) in APPL1 (显示 APPL1 抗体)/2 may be associated with CAD (显示 CAD 抗体) risk in T2DM in Chinese population.
Data suggest that although annexin A2 (显示 ANXA2 抗体) is not an exclusive marker of APPL1 (显示 APPL1 抗体)/2 endosomes, it has an important function in membrane recruitment of APPL (显示 APPL1 抗体) proteins, acting in parallel to Rab5 (显示 RAB5A 抗体).
significant fluorescence resonance energy transfer between APPL (显示 APPL1 抗体) minimal BAR domain FRET pairs
Here we establish potential roles for APPL1 (显示 APPL1 抗体) and 2 signaling adaptors as regulators of LPS/TLR4 (显示 TLR4 抗体)-induced signaling, transcription, and cytokine secretion.
Appl1 (显示 APPL1 抗体)/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 抗体)-induced Akt (显示 AKT1 抗体) activation, migration, and invasion.
Rab31 (显示 RAB31 抗体), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (显示 AKT1 抗体) signaling in macrophages.
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
DCC-interacting protein 13-beta
, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
, amyloid beta (A4) precursor-like protein 2
, DIP13 beta
, adapter protein containing PH domain, PTB domain and leucine zipper motif 2
, Dip3 beta