anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) 抗体

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. 再加上,我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9
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antibodies-online.cn销售最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 抗体

Showing 10 out of 36 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB Western blot analysis of APPL2 Antibody (N-term) Pab  pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. APPL2 Antibody (N-term) (arrow) was detected using the purified Pab. 400 μL Log in to see 10至11个工作日
$385.00
详细
小鼠 非结合性 IF, ELISA, WB Detection limit for recombinant GST tagged APPL2 is 0.3 ng/ml as a capture antibody. Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 monoclonal antibody (M06), clone 1C10.Lane 1: APPL2 transfected lysate (Predicted MW: 74.5 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 11至12个工作日
$440.00
详细
非结合性 WB Western Blot: DIP13B Antibody [NBP2-16165] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8至11个工作日
$516.98
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非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-16164] - Immunohistochemical analysis of paraffin-embedded HBL435 xenograft, using antibody at 1:100 dilution. Western Blot: DIP13B Antibody [NBP2-16164] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8至11个工作日
$516.98
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小鼠 非结合性 IF, WB Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 MaxPab polyclonal antibody.Lane 1: APPL2 transfected lysate(73.04 KDa).Lane 2: Non-transfected lysate. APPL2 MaxPab polyclonal antibody. Western Blot analysis of APPL2 expression in rat brain. 50 μg Log in to see 11至12个工作日
$440.00
详细
小鼠 非结合性 ELISA, WB   100 μg Log in to see 11至14个工作日
$837.83
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-14303] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. Western Blot: DIP13B Antibody [NBP2-14303] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY413268) 0.1 mL Log in to see 10至13个工作日
$494.38
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非结合性 ELISA, WB   200 μL Log in to see 11至16个工作日
$658.43
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HRP ELISA, WB   200 μL Log in to see 11至14个工作日
$1,013.83
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PE ELISA, WB   200 μL Log in to see 11至14个工作日
$1,013.83
详细

引用最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 抗体

  1. Human Polyclonal APPL2 Primary Antibody for IF, WB - ABIN527414 : Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011 (PubMed)

更多抗Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2的相互作用对抗体

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 gene provides a putative colorectal neoplasm progression index.

  2. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  3. ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  4. It concludes that APPL2(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin.

  5. C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.

  6. Data indicate that a high level of APPL2 protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  7. analysis of APPL1 and APPL2 proteins and their interaction with Rab

  8. found significant evidence of association with overweight/obesity for rs2272495 and rs1107756. rs2272495 C allele and rs1107756 T allele both conferred a higher risk of being overweight and obese.

  9. Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population.

  10. Data suggest that although annexin A2 is not an exclusive marker of APPL1/2 endosomes, it has an important function in membrane recruitment of APPL proteins, acting in parallel to Rab5.

  11. significant fluorescence resonance energy transfer between APPL minimal BAR domain FRET pairs

  12. identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 and APPL2, two Rab5 effectors

  13. The findings suggest a role for APPL1 and APPL2 protein as dynamic scaffolds that modulate RAB5-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding.

  14. APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. APPL2 overexpression could blunt the activation of glucocorticoid receptor when undergoing environmental stress.

  2. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4-induced signaling, transcription, and cytokine secretion.

  3. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF-induced Akt activation, migration, and invasion.

  4. Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) 抗原简介

蛋白简介

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) 抗体
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) 抗体
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) 抗体
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) 抗体
  • APPL2 抗体
  • Dip3b 抗体
  • DIP13B 抗体
  • MGC84621 抗体
  • RGD1563028 抗体

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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