anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) 抗体

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. 再加上,我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
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antibodies-online.cn销售最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体

Showing 10 out of 88 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg Log in to see 6至7个工作日
$429.62
详细
非结合性 IHC (p), WB Anti-APPL antibody, Western blotting WB: HELA Cell Lysate 100 μg Log in to see 4至6个工作日
$280.00
详细
山羊 非结合性 ELISA, WB Antibody (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.62
详细
Cow 非结合性 IHC, IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-APPL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other for ... 50 μg Log in to see 11至14个工作日
$727.83
详细
Cow 山羊 非结合性 WB   0.1 mg Log in to see 8至11个工作日
$462.00
详细
非结合性 ELISA, WB 100 μL Log in to see 16 Days
$181.73
详细
Cow 山羊 非结合性 ELISA, WB 100 μg Log in to see 7至9个工作日
$610.50
详细
山羊 非结合性 ELISA, WB Western Blot: APPL1 Antibody [ABIN252906] - APPL1 expression level after adenovirus transfection in rat aortic smooth muscle cells detected by ABIN252906. Western Blot: APPL Antibody [ABIN2529061] - Staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL adenovirus for 48hrs using ABIN2529061 at 0.5ug/ml. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 0.1 mg Log in to see 7至9个工作日
$485.88
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: APPL Antibody [NBP2-15434] - Paraffin-embedded AZ521 xenograft, using antibody at 1:100 dilution. Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8至11个工作日
$514.63
详细

引用最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody for ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal APPL1 Primary Antibody for ELISA, WB - ABIN252906 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006 (PubMed)

  3. Human Polyclonal APPL1 Primary Antibody for IHC (p), WB - ABIN3044289 : Huang, Zhang, Zhang, Ou, Pan: Effects of polysaccharides from Morchella conica on nitric oxide production in lipopolysaccharide-treated macrophages. in Applied microbiology and biotechnology 2012 (PubMed)

更多抗Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1的相互作用对抗体

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT (显示 ITK 抗体) via Akt2 (显示 AKT2 抗体) phosphorylation.

  2. APPL1 positively mediated leptin (显示 LEP 抗体) signaling.

  3. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  4. Results indicate that persistent rab5 (显示 RAB5A 抗体) overactivation through beta-cleaved carboxy-terminal fragment of APP (显示 APP 抗体)-APPL1 interactions constitutes a novel APP (显示 APP 抗体)-dependent pathogenic pathway in Alzheimer's disease

  5. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  6. Low expression of APPL1 is associated with metastasis in prostate cancer.

  7. APPL1 endosomes represent a distinct population of Rab5 (显示 RAB5A 抗体)-positive sorting endosomes.

  8. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (显示 TSC2 抗体)

  9. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  10. A role for APPL1 in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon (显示 IKBKE 抗体) activation in macrophages.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (显示 PRKCZ 抗体), as well as its functional interaction with both PP2A (显示 PPP2R2B 抗体) and myosin IIa.

  2. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

  3. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (显示 TLR4 抗体)-induced signaling, transcription, and cytokine secretion.

  4. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 抗体)-induced Akt (显示 AKT1 抗体) activation, migration, and invasion.

  5. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (显示 PRKAA1 抗体) signaling.

  6. A role for APPL1 in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon (显示 IKBKE 抗体) activation in macrophages.

  7. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

  8. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  9. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (显示 INS 抗体) sensitivity.

  10. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (显示 INS 抗体) resistance and improves adipoR1 (显示 ADIPOR1 抗体)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) 抗原简介

蛋白简介

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) 抗体
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Appl1) 抗体
  • 2900057D21Rik 抗体
  • 7330406P05Rik 抗体
  • AI585782 抗体
  • APPL 抗体
  • AW209077 抗体
  • BB022931 抗体
  • C88264 抗体
  • DIP13 抗体
  • DIP13alpha 抗体
  • RGD1309388 抗体

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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