anti-Activin Receptor Type I (ACRV1) 抗体

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. 再加上,我们可以发Activin Receptor Type I 蛋白 (35)Activin Receptor Type I 试剂盒 (16)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ACRV1 90 Q04771
ACRV1 79558 P80201
ACRV1 11477 P37172
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB WB Suggested Anti-ACVR1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Muscle 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB Host:  Rabbit  Target Name:  ACVR1  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml Host:  Rabbit  Target Name:  ACVR1  Sample Type:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center) (ABIN657777). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene. Anti-ACVR1 Antibody (Center) at 1:2000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 IHC (p), WB The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
$335.50
详细
山羊 非结合性 IHC, ELISA, WB ABIN238620 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
详细
小鼠 非结合性 ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using ACVR1 mAb against human ACVR1 (AA: 21-120) recombinant protein. (Expected MW is 37.1 kDa) 0.1 mg Log in to see 8至11个工作日
$561.00
详细
山羊 非结合性 CyTOF, FACS, IHC, WB Detection of Activin RIA/ALK-2 in PC-3 Human Cell Line by Flow Cytometry. Activin RIA/ALK-2 in Human Astrocytoma. 100 μg Log in to see 8至9个工作日
$433.55
详细
非结合性 EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate.ACVR1(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 EIA, WB Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细

引用最多的anti-Activin Receptor Type I 抗体

  1. Human Polyclonal ACRV1 Primary Antibody for CyTOF, FACS - ABIN4899715 : Fujimoto, Ohte, Shin, Yoneyama, Osawa, Miyamoto, Tsukamoto, Mizuta, Kokabu, Machiya, Okuda, Suda, Katagiri: Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2. in Biochemical and biophysical research communications 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal ACRV1 Primary Antibody for IHC (p), WB - ABIN392240 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal ACRV1 Primary Antibody for IHC (p), IHC - ABIN256737 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)

更多抗Activin Receptor Type I的相互作用对抗体

Human Activin Receptor Type I (ACRV1) interaction partners

  1. Results showed that ACVR1 was a direct target of miR (显示 MLXIP 抗体)-384 and was involved in the inhibitory effects of miR (显示 MLXIP 抗体)-384 on breast cancer progression. Furthermore, the study indicated that ACVR1 activated the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway in breast cancer.

  2. Study emphasizes about the role of ACVR1 which encoding a receptor for BMP proteins in fibrodysplasia ossificans progressiva (FOP). Most FOP patients carry the recurrent R206H substitution in the GS domain, whereas a few other mutations are responsible for limited cases. Mutations cause a dysregulation of the downstream BMP-dependent pathway making mutated ACVR1 responsive to a non-canonical ligand, Activin A (显示 INHBA 抗体). [review]

  3. The role of an ALK2 mutation (R258S) in IRIDA (显示 TMPRSS6 抗体) development in a patient also bearing compound heterozygous mutations in TMPRSS6 (显示 TMPRSS6 抗体) was demonstrated by reconstructing in vitro the proband's genotype, expressing mutants TMPRSS6 (显示 TMPRSS6 抗体) and ACVR1 in the presence of hemojuvelin (显示 HFE2 抗体) and assessing hepcidin (显示 HAMP 抗体) activation. ALK2(R258S) maintained high hepcidin (显示 HAMP 抗体) expression in the presence of MT2 (显示 MT2 抗体)(I212T).

  4. activation of AMPK (显示 PRKAA1 抗体) upregulated Smad6 (显示 SMAD6 抗体) and Smurf1 (显示 SMURF1 抗体) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2.

  5. the Fibrodysplasia Ossificans Progressiva mutation ACVR1(R206H) is more sensitive to a number of natural ligands.

  6. both bone morphogenetic protein 2 (BMP2 (显示 BMP2 抗体)) and BMP6 (显示 BMP6 抗体) are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (显示 BMPR1A 抗体)) and ALK2, play crucial and distinct roles in this process.

  7. Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1. Developed is a simplified one-step procedure by simultaneously introducing reprogramming and gene-editing components into human fibroblasts derived from patient with FOP. The one-step-mediated ALK2 gene-corrected induced pluripotent stem cells restored global gene expression pattern.

  8. The ACVR1 R206H mutation may not directly increase the formation of mature chondrogenic or osteogenic cells.

  9. Authors demonstrated that the BMP type I receptor ALK-2 (encoded by the ACVR1 gene) has crucial roles in apoptosis induction of patient-derived glioma-initiating cells (GICs), TGS (显示 LIN9 抗体)-01 and TGS (显示 LIN9 抗体)-04.

  10. Data suggest BMP9/GDF2 (显示 GDF2 抗体) and BMP10 (显示 BMP10 抗体) synergize with TNFA (显示 TNF 抗体) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase (显示 CDK7 抗体) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 (显示 GDF2 抗体) = growth differentiation factor 2 (显示 GDF2 抗体); BMP10 (显示 BMP10 抗体) = bone morphogenetic protein 10 (显示 BMP10 抗体); TNFA (显示 TNF 抗体) = tumor necrosis factor alpha (显示 TNF 抗体); ALK2/ACVR1 = activin A receptor type 1)

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. findings demonstrate that hair follicle specific ALK2 is intricately involved in maintenance of the stem cell niche and wound healing

  2. NODAL/Activin (显示 Actbeta 抗体) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2 (显示 SMAD2 抗体), acting via multiple mechanisms.

  3. Acute tacrolimus treatment transiently increases hepcidin (显示 HAMP 抗体) in wild-type mice. FKBP12 (显示 FKBP1A 抗体) preferentially targets the BMP receptor (显示 BMPR1A 抗体) ALK2. ALK2 mutants defective in binding FKBP12 (显示 FKBP1A 抗体) increase hepcidin (显示 HAMP 抗体) expression in a ligand-independent manner, through BMP-SMAD (显示 SMAD1 抗体) signaling.

  4. The authors demonstrated that ubiquitin-specific protease (USP) 4 (显示 USP4 抗体) strongly induces activin (显示 Actbeta 抗体)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (显示 SMAD4 抗体).

  5. Enhanced SMAD (显示 SMAD1 抗体)-dependent BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice, via medial-edge-epithelium persistence presumably due to the up regulation of DeltaNp63 andresultingreductionofcaspase-3 activation. 2.

  6. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A (显示 BMPR1A 抗体), and BMPR2 (显示 BMPR2 抗体) is an essential proangiogenic cue for retinal vessels.

  7. This study showed that Gja1 (显示 GJA1 抗体) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2 (显示 HAND2 抗体).

  8. Results showed activin (显示 Actbeta 抗体)-C and follistatin (显示 FST 抗体) are differentially expressed during prostate development and suggested that the antagonistic property of follistatin (显示 FST 抗体) is secondary to the action of activin (显示 Actbeta 抗体)-C. Study provides evidence to support a role of activin (显示 Actbeta 抗体)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

  9. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling

  10. Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell (显示 NFATC3 抗体) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

Horse (Equine) Activin Receptor Type I (ACRV1) interaction partners

  1. Data suggest that ACVR1 mRNA and protein are present in granulosa cells of ovarian follicles at mid-estrous and pre-ovulatory stages; ACVR1 mRNA and protein are also present in exosomes isolated from mid-estrous and preovulatory follicles.

Activin Receptor Type I (ACRV1) 抗原简介

蛋白简介

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor type 1 (ACVR1) 抗体
  • activin A receptor type 2B (ACVR2B) 抗体
  • activin A receptor type 1 (Acvr1) 抗体
  • activin A receptor, type 1 (Acvr1) 抗体
  • activin A receptor type 1 S homeolog (acvr1.S) 抗体
  • ActR-I 抗体
  • ActR-IA 抗体
  • actri 抗体
  • ActRIA 抗体
  • Acvr 抗体
  • acvr1 抗体
  • acvr1-a 抗体
  • acvr1-b 抗体
  • acvr1a 抗体
  • acvrlk2 抗体
  • alk-2 抗体
  • alk2 抗体
  • alk8 抗体
  • D330013D15Rik 抗体
  • fop 抗体
  • sax 抗体
  • skr1 抗体
  • Tsk7L 抗体
  • tsri 抗体
  • xALK-2 抗体

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 2 , activin receptor type I , activin receptor type-1 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , serine/threonine-protein kinase receptor R1 , ACTR-IIB , activin receptor type IIB , activin receptor type-2B , ACTR-I , SKR1 , TSR-I , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA , TSK-7L , activin A receptor type 1 S homeolog , activin A receptor type I S homeolog , activin receptor like kinase-2

GENE ID SPECIES
90 Homo sapiens
374213 Gallus gallus
79558 Rattus norvegicus
338068 Bos taurus
395246 Gallus gallus
443161 Ovis aries
11477 Mus musculus
478757 Canis lupus familiaris
100724428 Cavia porcellus
399083 Xenopus laevis
100050899 Equus caballus
697935 Macaca mulatta
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