Activin A Receptor Type II-Like 1 (ACVRL1) ELISA试剂盒

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. 再加上,我们可以发ACVRL1 抗体 (158)ACVRL1 蛋白 (23)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
ACVRL1 94 P37023
ACVRL1 25237 P80203
ACVRL1 11482 Q61288
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适于 ACVRL1 相互作用对的更多 ELISA 试剂盒

Cow (Bovine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Results show that ALK5 (显示 TGFBR1 ELISA试剂盒) and ALK1 play antagonistic roles in TGF-beta (显示 TGFB1 ELISA试剂盒)-induced podosome formation in aortic endothelial cells.

  2. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

Zebrafish Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. alk1 loss has no effect on arterial endothelial cell proliferation but alters arterial endothelial cell migration within lumenized vessels.

  2. Control of Notch (显示 NOTCH1 ELISA试剂盒) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (显示 NOTCH1 ELISA试剂盒) and Alk1

  3. Blood flow is required not only for alk1 expression but also for Alk1 activity.

  4. Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.

  5. vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (显示 TGFB1 ELISA试剂盒) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.

Human Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Treatment-related telangiectasia was noted in 7% of patients, suggesting in vivo inhibition of the ALK-1 pathway.

  2. Data indicate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 and VEGFR, is a valid strategy for treatment of metastatic renal cell carcinoma (mRCC).

  3. Study showed that rs706819, rs2293094, and rs11169953 polymorphisms in the ACVRL1 gene are associated with higher susceptibility to brain arteriovenous malformations.

  4. c.1027C > T(p.Gln343) mutation within the ACVRL1 gene in family with hereditary hemorrhagic telangiectasia

  5. Bone morphogenetic protein (BMP)9 (显示 GDF2 ELISA试剂盒) and BMP10 (显示 BMP10 ELISA试剂盒) are high affinity ligands for activin receptor-like kinase 1 (ALK1).

  6. Activin receptor-like kinase (ALK)1 is a transforming growth factor beta (TGF-beta) type I receptor (显示 TGFBR1 ELISA试剂盒) predominantly expressed in actively proliferating endothelial cells (ECs).

  7. Two novel missense mutations and two recurrent mutations in the ACVRL1 gene are associated with pulmonary arterial hypertension in in Chinese families.

  8. ALK1 expression and microvessel density are increased in oral lichen planus , particularly in atrophic/erosive OLP type.

  9. The genetic-interactions among BMPR-2 (显示 BMPR2 ELISA试剂盒), ALK-1, and 5-HTT (显示 SLC6A4 ELISA试剂盒) polymorphisms, elevated BMP-2 (显示 BMP2 ELISA试剂盒) and 5-HT (显示 DDC ELISA试剂盒) levels and differential gene expression substantiated the strong genetic contribution in high altitude pulmonary edema pathophysiology.

  10. Study of four patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection found predisposing mutations in the BMPR2 (显示 BMPR2 ELISA试剂盒), ACVRL1 and ENG (显示 ENG ELISA试剂盒) genes.

Mouse (Murine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF (显示 VEGFA ELISA试剂盒). Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.

  2. these studies characterize an accessory TGF-beta (显示 TGFB1 ELISA试剂盒)-stimulated BMP R-Smad (显示 SMAD1 ELISA试剂盒) signaling mechanism in interstitial cells of the developing lung.

  3. this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development.

  4. CD109 (显示 CD109 ELISA试剂盒) differentially regulates TGF-beta (显示 TGFB1 ELISA试剂盒)-induced ALK1-Smad1 (显示 SMAD1 ELISA试剂盒)/5 versus ALK5 (显示 TGFBR1 ELISA试剂盒)-Smad2 (显示 SMAD2 ELISA试剂盒)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (显示 CD109 ELISA试剂盒) expression regulates dermal function through a paracrine mechanism

  5. he results of the present study demonstrated that BMP9 (显示 GDF2 ELISA试剂盒) promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 (显示 MAPK1/3 ELISA试剂盒) signaling pathways in the cell

  6. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.

  7. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  8. In vascular sprouting, neuropilin-1 (显示 NRP1 ELISA试剂盒) suppresses the stalk-cell phenotype by limiting Smad2 (显示 SMAD2 ELISA试剂盒)/3 activation through Alk1 and Alk5 (显示 TGFBR1 ELISA试剂盒). Notch (显示 NOTCH1 ELISA试剂盒) downregulates Nrp1 (显示 NRP1 ELISA试剂盒), thus relieving the inhibition of Alk1 and Alk5 (显示 TGFBR1 ELISA试剂盒), thereby driving stalk-cell behaviour.

  9. BMP9 (显示 GDF2 ELISA试剂盒)/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9 (显示 GDF2 ELISA试剂盒)/ALK1 may improve the efficacy of EPC (显示 TCF21 ELISA试剂盒)-based therapies for treating ischemic diseases.

  10. BMP-9 (显示 GDF2 ELISA试剂盒) induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad (显示 SMAD1 ELISA试剂盒) and ALP dependent mechanisms.

ACVRL1 抗原简介

Antigen Summary

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Gene names and symbols associated with ACVRL1

  • activin A receptor like type 1 (ACVRL1) 抗体
  • activin A receptor type II-like 1 (ACVRL1) 抗体
  • activin A receptor like type 1 (acvrl1) 抗体
  • activin A receptor like type 1 (Acvrl1) 抗体
  • activin A receptor, type II-like 1 (Acvrl1) 抗体
  • ACVRL1 抗体
  • Acvrlk1 抗体
  • AI115505 抗体
  • AI427544 抗体
  • ALK-1 抗体
  • Alk1 抗体
  • HHT 抗体
  • HHT2 抗体
  • hm:zehn1109 抗体
  • ORW2 抗体
  • R-3 抗体
  • R3 抗体
  • SETHKIR 抗体
  • SKR3 抗体
  • TSR-I 抗体
  • vgb 抗体
  • zehn1109 抗体

Protein level used designations for ACVRL1

activin A receptor type II-like 1 , serine/threonine-protein kinase receptor R3 , serine/threonine-protein kinase receptor R3-like , activin receptor-like kinase 1 , vbg , violet beauregarde , TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 1 , Activin receptor like kinase 1 , SKR3 , TSR-I , ALK-1 , activin receptor-like kinase-1

GENE ID SPECIES
451910 Pan troglodytes
534536 Bos taurus
696471 Macaca mulatta
100061313 Equus caballus
100135773 Felis catus
100482358 Ailuropoda melanoleuca
266753 Danio rerio
94 Homo sapiens
25237 Rattus norvegicus
477603 Canis lupus familiaris
100153279 Sus scrofa
100172614 Pongo abelii
11482 Mus musculus
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