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The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. 再加上，我们可以发ACO2 抗体 (131) 和 ACO2 蛋白 (8)和数多这个蛋白质的别的产品。
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The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers.
Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection
Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.
immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men
Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells
Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.
Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.
these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.
abolishes oxidant-induced apoptosis
Lon protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification, but that severe oxidation results in aconitase aggregation, which makes it a poor substrate for Lon.
ACO2 is often deleted in colorectal cancer but is unlikely to be the true target of the deletions
The m-aconitase promoter is contained in a 153-bp 5' fragment lacking a TATA or CAAT sequence. Sp1 binding to specific Sp1 site is needed for promoter activity. Other transcription factors are recruited through protein-protein interactions.
Manganese acts as an antagonist of iron, disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate.
This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.
This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Activation of mitochondrial aconitase is acetylation-dependent.
IRP-1,-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development
aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation
study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
aconitate hydratase, mitochondrial
, mitochondrial aconitate hydratase
, aconitase 2, mitochondrial
, aconitate hydratase, mitochondrial-like
, citrate hydro-lyase
, mitochondrial aconitase (nuclear aco2 gene)
, heart aconitase