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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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ABCB1 (显示 ABCB1 抗体) gene polymorphisms are not associated with response to chemotherapy in breast cancer.
Patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05).
Genotypes of UGT1A (显示 UGT1A1 抗体) and ABCB1 (显示 ABCB1 抗体) were significantly associated with changes in moxifloxacin pharmacokinetic parameters.
G2677T/A polymorphism of MDR1 (显示 TBC1D9 抗体) may play a significant role in the development of drug-resistant epilepsy in the Polish patients
No association was found between the ABCB1 (显示 ABCB1 抗体) SNPs and Crohn's disease in the two populations
icaritin (ICT) decreased the mRNA and protein levels of multidrug resistance protein 1 (MDR1 (显示 ABCB4 抗体)) in MG-63 doxorubicin-resistant (MG-63/DOX) cells.
We demonstrate for the first time that the effect of ABCB1 (显示 ABCB1 抗体) diplotype on tacrolimus disposition is dependent on both CYP3A5 (显示 CYP3A5 抗体) and CYP3A4 (显示 CYP3A4 抗体) genotype.
these results address key concerns in the field, including that of cross-resistance between taxanes and highlighting a mechanism of cabazitaxel resistance involving ABCB1 (显示 ABCB1 抗体)
CYP3A (显示 CYP3A4 抗体) and ABCB1 (显示 ABCB1 抗体) SNPs were detected in 521 recipients.
MDR-1 (显示 TBC1D9 抗体) C3435T gene polymorphism was associated with right ventricular dysfunction in patients with chronic obstructive pulmonary disease.
A panel of 18 P-gp (显示 ABCB4 抗体) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (显示 ABCB4 抗体)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (显示 ABCB4 抗体) can affect the pulmonary kinetics of a subset of P-gp (显示 ABCB4 抗体) substrates.
Data suggest that the overexpression of P-gp (显示 ABCB4 抗体) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (显示 ABCB4 抗体), multi-drug resistance protein, MDR1 (显示 ABCB4 抗体)).Drugs with ER < 1 (显示 MIER1 抗体) almost do not bind the main binding cavity (MBC (显示 CACNA1C 抗体)) of P-gp (显示 ABCB4 抗体).
conclusion, MDR1 (显示 ABCB4 抗体) and BCRP are expressed on apical membranes of the rodent placental SynT (显示 STX1A 抗体)-II layer.
Mdr1 (显示 ABCB4 抗体) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (显示 ABCB1 抗体) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (显示 ABCB4 抗体) ATPase (显示 DNAH8 抗体) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (显示 ABCB4 抗体) activity and reverse the up-regulated P-gp (显示 ABCB4 抗体) and MDR1 (显示 ABCB4 抗体) levels induced by artemisinin.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1