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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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MDR1 (显示 TBC1D9 抗体) is not expressed on erythrocyte membrane.
The genetic polymorphisms of the multi-drug resistance-1 (MDR-1 (显示 TBC1D9 抗体)) and human cytochrome P450 (显示 CYP 抗体) 3A (CYP3A4 (显示 CYP3A4 抗体) and CYP3A5 (显示 CYP3A5 抗体)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.
This meta-analysis suggests that the MDR1 (显示 TBC1D9 抗体) C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.
High MDR1 (显示 TBC1D9 抗体) expression is associated with chemoresistance in ovarian cancer.
13-cis (显示 CISH 抗体)-retinoic acid, retinol and retinyl-acetate inhibited the Pgp (显示 PGPEP1 抗体) and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase (显示 DNAH8 抗体) activity of these transporters.
Haplotype analysis of ABCB1 (显示 ABCB1 抗体) conducted in patients with bullous pemphigoid (显示 DST 抗体) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 (显示 ABCB1 抗体) expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1 (显示 TBC1D9 抗体)) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 (显示 ABCB1 抗体) variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 (显示 TBC1D9 抗体) gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (显示 STS 抗体). In addition, high MDR1 (显示 TBC1D9 抗体) expression was significantly associated with local advances, as well as poor response to treatment.
this study shows that MDR1 (显示 ABCB4 抗体) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (显示 ABCB4 抗体) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (显示 ABCB4 抗体)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (显示 ABCB4 抗体) can affect the pulmonary kinetics of a subset of P-gp (显示 ABCB4 抗体) substrates.
Data suggest that the overexpression of P-gp (显示 ABCB4 抗体) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (显示 ABCB4 抗体), multi-drug resistance protein, MDR1 (显示 ABCB4 抗体)).Drugs with ER < 1 (显示 MIER1 抗体) almost do not bind the main binding cavity (MBC (显示 CACNA1C 抗体)) of P-gp (显示 ABCB4 抗体).
conclusion, MDR1 (显示 ABCB4 抗体) and BCRP are expressed on apical membranes of the rodent placental SynT (显示 STX1A 抗体)-II layer.
Mdr1 (显示 ABCB4 抗体) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (显示 ABCB1 抗体) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (显示 ABCB4 抗体) ATPase (显示 DNAH8 抗体) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1