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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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This study demonstrated that the The G2677T T and C3435T T alleles as well as the TT, CTT (显示 TNNT2 抗体) and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in Tunisian epileptic population.
Pharmacokinetics of aripiprazole is affected by sex and ABCB1 (显示 ABCB1 抗体) gene phenotype
There were no significant differences in the bosutinib C0 between genotypes for ABCB1 (显示 ABCB1 抗体), ABCG2, and CYP3A4 (显示 CYP3A4 抗体) polymorphisms.
Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG (显示 UGCG 抗体)) and multidrug resistance protein 1 (MDR1 (显示 ABCB4 抗体)) overexpression and multidrug resistance development [Review].
Due to the downregulation of MDR1 (显示 TBC1D9 抗体) and MRP1 (显示 MDM4 抗体), the intracellular accumulation of ADM (显示 ADM 抗体) was increased in the transfected cells compared with that in the parental K562/ADM (显示 ADM 抗体) cells..Our research revealed that protein expression of the ERK (显示 EPHB2 抗体) signaling pathway was inhibited by downregulating TRIB2 (显示 TRIB2 抗体), indicating that the ERK (显示 EPHB2 抗体) pathway was involved in cell drug resistance and proliferation.
Asiatic Acid strongly inhibited P-GP (显示 ABCB4 抗体) expression by blocking MDR1 (显示 TBC1D9 抗体) gene transcription and increased the intracellular accumulation of the P-GP (显示 ABCB4 抗体) substrate Rhodamine 123 in MDR1 (显示 TBC1D9 抗体)-overexpressing cisplatin (DDP (显示 TIMM8A 抗体))-resistant lung cancer cells, A549/DDP (显示 TIMM8A 抗体).
Ceritinib enhanced the efficacy of substrate chemotherapeutic agent in ABCB1 (显示 ABCB1 抗体)-overexpressing K562/adr (显示 AKR1B1 抗体) leukemia cells both in vitro and in vivo models, but neither in sensitive parental K562 leukemia cells nor in ABCC1 (显示 ABCC1 抗体)-overexpressing HL-60/adr (显示 AKR1B1 抗体) leukemia cells.
Polymorphism of ABCB1 (显示 ABCB1 抗体) rs1045642-T variant allele is associated with colorectal cancer.
There is a certain correlation between the APC (显示 APC 抗体) gene and ovarian tumors, and the APC (显示 APC 抗体) gene mediates the apoptosis of tumor cells through the MDR-1 (显示 TBC1D9 抗体)/CLCX-1 signaling pathway.
ABCB1/Pgp (显示 ABCB4 抗体) expression, activity, and single nucleotide polymorphisms (SNPs) in chronic myeloid leukemia (显示 BCL11A 抗体). [review]
this study shows that MDR1 (显示 ABCB4 抗体) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (显示 ABCB4 抗体) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (显示 ABCB4 抗体)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (显示 ABCB4 抗体) can affect the pulmonary kinetics of a subset of P-gp (显示 ABCB4 抗体) substrates.
Data suggest that the overexpression of P-gp (显示 ABCB4 抗体) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (显示 ABCB4 抗体), multi-drug resistance protein, MDR1 (显示 ABCB4 抗体)).Drugs with ER < 1 (显示 MIER1 抗体) almost do not bind the main binding cavity (MBC (显示 CACNA1C 抗体)) of P-gp (显示 ABCB4 抗体).
conclusion, MDR1 (显示 ABCB4 抗体) and BCRP are expressed on apical membranes of the rodent placental SynT (显示 STX1A 抗体)-II layer.
Mdr1 (显示 ABCB4 抗体) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (显示 ABCB1 抗体) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (显示 ABCB4 抗体) ATPase (显示 DNAH8 抗体) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1