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ARL11 encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins.
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ARLTS1 gene mutations can be considered as a potential predisposing factor in familial hematological malignancies
A statistically significant (p = 0.0037) decrease of ARLTS1 expression in prostate cancer cases was detected.
the important role of ARLTS1 Cys148Arg variant as a contributor in prostate cancer predisposition
A significantly increased risk was observed for young ovarian cancer patients with ARLTS1 Cys148Arg variant.
The role of the allelic variants in ARLTS1, RAD51 (显示 RAD51 抗体) and MDM2 (显示 MDM2 抗体) acting in the tumor suppressor, DNA repair and p53 (显示 TP53 抗体) pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease, was investigated.
A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation factor (显示 ARF1 抗体)-like tumor suppressor gene 1)]is found to be altered in human carcinogenesis. It is located in Chromosome 13q14.3.
A genetic variant of ARLTS1 predisposes patients to familial cancer.
the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer
The study does not support the postulate that variants of ARLTS1 influence the risk of chronic lymphocytic leukemia(CLL).
While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02)
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers.
ADP-ribosylation factor-like protein 11
, ADP-ribosylation factor-like 11
, ADP-ribosylation factor-like tumor suppressor protein 1