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ADAMTS18 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
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Human Polyclonal ADAMTS18 Primary Antibody for FACS, IHC (p) - ABIN652853
Zeng, Corcoran, Collins-Racie, Lavallie, Morris, Flannery: Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. in Biochimica et biophysica acta 2006
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The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation.
Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model.
these data demonstrate a thrombin (显示 F2 抗体) cleavage site and confirm a short form of ADAMTS-18 presents in vivo.
Adamts18 is expressed in the lens and retina in the developing murine eye.
In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT (显示 AKT1 抗体) and NF-kappaB (显示 NFKB1 抗体) signaling, further suppressing EMT (显示 ITK 抗体) and metastasis of breast cancer cells.
This study showed that ADAMTS1 (显示 ADAMTS1 抗体), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
Studies suggest that ADAM metallopeptidase (显示 ECEL1 抗体) with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target.
Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers
Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia.
study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases
the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation.
ADAMTS18 mutations promote growth, migration, and metastasis in melanoma
ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM (显示 ODZ1 抗体) staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis.
comparison of the effects of C-terminal truncation on the GAG-binding properties and aggrecanase (显示 ADAMTS4 抗体) activity of ADAMTS-5 (显示 ADAMTS5 抗体) relative to three other ADAMTS (显示 ADAMTS13 抗体) family members, ADAMTS-9 (显示 ADAMTS9 抗体), ADAMTS-16 (显示 ADAMTS16 抗体) and ADAMTS-18
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
A disintegrin and metalloproteinase with thrombospondin motifs 18
, ADAM-TS 18
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21
, disintegrin and metalloprotease-like protein
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18