anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) 抗体

ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. 再加上,我们可以发ADAMTS13 试剂盒 (28)ADAMTS13 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ADAMTS13 11093 Q76LX8
ADAMTS13 279028 Q769J6
ADAMTS13 102554393  
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antibodies-online.cn销售最多的anti-ADAMTS13 抗体

Showing 10 out of 91 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 EIA, IHC (p), WB Immunohistochemistry: ADAMTS13 antibody staining of Formalin-Fixed Paraffin-Embedded Human hepatocarcinoma followed by peroxidase-conjugation to the secondary antibody and DAB staining. Western blot analysis: ADAMTS13 antibody staining of CEM cell line lysates (35 µg/lane). ADAMTS13 (arrow) was detected using the purified Pab. 0.4 mL 6至8个工作日
$484.00
详细
非结合性 ELISA, WB Western blot analysis of ADAMTS13 expression in rat brain extract ( Lane 1), mouse liver extract ( Lane 2) and HEPG2 whole cell lysates ( Lane 3). ADAMTS13 at 154KD was detected using rabbit anti- ADAMTS13 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4至6个工作日
$240.00
详细
非结合性 ELISA, IHC, WB Western blot analysis of ADAMTS13 using HeLa whole cell lysates ABIN6279085 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11至12个工作日
$390.77
详细
非结合性 IHC (p), WB Western blot analysis of anti-ADAMTS13 Antibody in CEM cell line lysates (35ug/lane) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2至3个工作日
$515.63
详细
山羊 非结合性 IHC, IHC (p), WB Anti-ADAMTS13 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μL 11至14个工作日
$639.83
详细
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded liver tissue 100 μg 13至16个工作日
$240.00
详细
小鼠 非结合性 IF, ELISA, WB   100 μg 11至14个工作日
$1,013.83
详细
小鼠 非结合性 ELISA, WB   100 μg 11至14个工作日
$1,189.83
详细
绵羊 Biotin WB   50 μg 11至14个工作日
$1,255.83
详细
小鼠 非结合性 FACS, IP, ELISA, WB   100 μg 11至14个工作日
$1,013.83
详细

引用最多的anti-ADAMTS13 抗体

  1. Human Polyclonal ADAMTS13 Primary Antibody for WB - ABIN152016 : Tao, Wang, Choi, Bernardo, Nishio, Sadler, López, Dong: Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. in Blood 2005 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal ADAMTS13 Primary Antibody for IP, WB - ABIN251718 : Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. in Blood 2013 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ADAMTS13 Primary Antibody for WB - ABIN251717 : Turner, Nolasco, Ruggeri, Moake: Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. in Blood 2009 (PubMed)

更多抗ADAMTS13的相互作用对抗体

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. higher VWF and low ADAMTS13 activity are associated with increased risk of dementia

  2. Data confirm the critical role of exosite engagement for substrates to gain access to the active site of ADAMTS13, and define the substrate recognition motif for ADAMTS13.

  3. Trp(390) residue within the WXXW motif is required for ADAMTS13 secretion and enzymatic activity

  4. ADAMTS13 open-closed conformations regulate the activity of this highly specific VWF cleaving protease in thrombotic thrombocytopenic purpura [review]

  5. analysis of a follow-up study showing higher mortality or thrombotic complications and increased platelet count, increased VWF:Ag levels and decreased ADAMTS13 activity in colorectal cancer

  6. relative plasma deficiency of ADAMTS13 activity may be associated with more severe traumatic injury, significant endothelial glycocalyx damage, coagulation abnormalities and mortality after severe trauma in paediatric patients

  7. Low ADAMTS-13 activity is a predictor of unfavourable outcome in patients with ischaemic stroke undergoing endovascular therapy

  8. analysis of ADAMTS13 variants in a patient cohort with Upshaw-Schulman Syndrome investigated in Germany

  9. Through its action on VWF, ADAMTS13 can have prothrombotic and proinflammatory properties, not only when its activity is severely deficient, but also when it is only moderately low.

  10. An open ADAMTS-13 conformation is also a hallmark of acute acquired thrombotic thrombocytopenic purpura, altering autoantibody binding.

  11. truncation of ADAMTS13 by plasmin abolishes intramolecular self-association, which improves interaction with unfolded von Willebrand Factor

  12. antigen and activity both positively correlated with plasma viral load in HIV infection

  13. protein C and ADAMTS-13 change were associated with outcome in an ongoing endothelial/hemostatic disorder was during sepsis

  14. Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene.

  15. ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.

  16. Genetic analysis of 5 children with congentical thrombotic thrombocytopenia purpura showed complex heterozygous mutations at different loci of ADAMTS13 gene

  17. this study shows that in Upshaw-Schulman syndrome, age-onset defines two entities and ADAMTS13 sequence variations modify ADAMTS13 conformation

  18. acute myeloid leukemia patients with low activity of ADAMTS-13 had worse prognosis after bone morrow transplantation.

  19. The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis

  20. The aim of the study was to investigate the role of von Willebrand factor (vWF), the vWF-cleaving protease, ADAMTS13, the composition of thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke.

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. ADAMTS13 knockout promotes the occurrence of early brain injury after experimental subarachnoid hemorrhage.

  2. ADAMTS13-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

  3. Adamts13 deficiency in obese mice promotes hepatic microthrombosis.

  4. results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.

  5. ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis.

  6. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes

  7. Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

  8. Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

  9. Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

  10. ADAMTS13 substrate specificity

  11. Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

  12. Data show that metalloendopeptidase ADAMTS13 does not directly promote development of adipose tissue.

  13. findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF axis in atherosclerosis

  14. Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

  15. Three novel mutations in a homozygous state were identified in these patients: c.1308G>C, c.428T>C (p.Ile143Thr) and c.1709A>G (p.Tyr570Cys)

  16. The results indicate that the microvascular process induced by ADAMTS13 deficiency triggers complement activation on platelets and the endothelium, which may contribute to formation of thrombotic microangiopathy.

  17. model of acute myocardial infarction in ADAMTS13 gene deleted (Adamts13 -/-) mice

  18. We hypothesize that ADAMTS13 protects brain from ischemia-reperfusion injury by regulating von Willebrand factor -dependent inflammation as well as microvascular plugging

  19. Cyclophilin B activity regulated secretion and activity of ADAMTS13.

  20. Adamts13(-/-) mice developed larger myocardial infarctions than wild-type control mice.

ADAMTS13 抗原简介

蛋白简介

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Gene names and symbols associated with ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13) 抗体
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13) 抗体
  • ADAM-TS13 抗体
  • ADAMTS-13 抗体
  • ADAMTS13 抗体
  • C9orf8 抗体
  • Gm710 抗体
  • vWF-CP 抗体
  • VWFCP 抗体

Protein level used designations for ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif, 13 , A disintegrin and metalloproteinase with thrombospondin motifs 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , vWF-cleaving protease , von Willebrand factor-cleaving protease , ADAM-TS 13 , ADAM-TS13 , ADAMTS-13 , ADAMTS13 isoform IAP-b , vWF-CP mRNA for von Willebrand factor-cleaving , ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like , A disintegrin and metalloproteinase with thrombospondin motifs 13-like , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

GENE ID SPECIES
100069281 Equus caballus
11093 Homo sapiens
279028 Mus musculus
532272 Bos taurus
100320289 Danio rerio
100404947 Callithrix jacchus
100343027 Oryctolagus cuniculus
100481099 Ailuropoda melanoleuca
100226372 Taeniopygia guttata
100630922 Canis lupus familiaris
102554393 Rattus norvegicus
100727045 Cavia porcellus
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