ABCG8 产品
(ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8))
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
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Featured ABCG8 Categories
Recommended ABCG8 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (5)
Cat. No.
ABIN3022643
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7144942
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6259696
Quantity
100 μL
Datasheet
Datasheet
Recommended ABCG8 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3118045
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3129571
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3087977
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ABCG8 Products
: "Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice." in: Gastroenterology research and practice, Vol. 2020, pp. 1343969, (2020) (PubMed).: "Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function." in: Cell death & disease, Vol. 9, Issue 2, pp. 173, (2019) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).
: "On the regulatory importance of 27-hydroxycholesterol in mouse liver." in: The Journal of steroid biochemistry and molecular biology, (2016) (PubMed).
: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).
: "Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model." in: Endocrinology, Vol. 156, Issue 12, pp. 4545-57, (2015) (PubMed).
: "Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice." in: Journal of lipid research, Vol. 55, Issue 3, pp. 540-8, (2014) (PubMed).
: "Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter." in: Scientific reports, Vol. 4, pp. 4258, (2014) (PubMed).
: "Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice." in: Applied and environmental microbiology, Vol. 80, Issue 24, pp. 7496-504, (2014) (PubMed).
: "Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease." in: Digestive diseases and sciences, Vol. 59, Issue 12, pp. 2975-82, (2014) (PubMed).
Synonyms and alternative names related to ABCG8
ATP binding cassette subfamily G member 8 (ABCG8), ATP-binding cassette sub-family G member 8 (PTRG_02054), ABC transporter G family protein (abcG8), ATP-binding cassette, sub-family G (WHITE), member 8 (abcg8), ATP binding cassette subfamily G member 8 (Abcg8), 1300003C16Rik, AI114946, DDBDRAFT_0167690, DDBDRAFT_0191232, DDB_0167690, DDB_0191232, GBD4, sterolin-2, STSL, zgc:172358Protein level used designations for ABCG8
- ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
- sterolin 2
- ATP-binding cassette sub-family G member 8
- sterolin-2
- ATP-binding cassette, sub-family G (WHITE), member 8
- ATP-binding cassette sub-family G member 8-like
- ATP-binding cassette, subfamily G, member 8
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