(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected\; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008].
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Naud, Laurin, Michaud, Beauchemin, Leblond, Pichette: "Effects of chronic renal failure on brain drug transporters in rats." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 1, pp. 39-46, (2011) (PubMed).
Meyer Zu Schwabedissen, Grube, Heydrich, Linnemann, Fusch, Kroemer, Jedlitschky et al.: "Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular ..." in: The American journal of pathology, Vol. 166, Issue 1, pp. 39-48, (2005) (PubMed).
Aliases for ABCC5 抗体
ATP binding cassette subfamily C member 5 (ABCC5) 抗体 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (Abcc5) 抗体 ATP binding cassette subfamily C member 5 (Abcc5) 抗体 ATP binding cassette subfamily C member 5 L homeolog (abcc5.L) 抗体 2900011L11Rik 抗体 ABC33 抗体 abc33 抗体 abcc5 抗体 Abcc5a 抗体 Abcc5b 抗体 AI132311 抗体 EST277145 抗体 MOAT-C 抗体 moat-c 抗体 MOATC 抗体 moatc 抗体 MRP5 抗体 Mrp5 抗体 mrp5 抗体 pABC11 抗体 pabc11 抗体 SMRP 抗体 smrp 抗体