AAK1 抗体
(AP2 associated kinase 1 (AAK1))
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Latest Publications for our AAK1 抗体
: "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway." in: Molecular biology of the cell, Vol. 18, Issue 7, pp. 2698-706, (2007) (PubMed).: "Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells." in: Oncogene, Vol. 20, Issue 36, pp. 4995-5004, (2001) (PubMed).
: "Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling." in: Oncogene, Vol. 19, Issue 39, pp. 4461-8, (2000) (PubMed).
Aliases for AAK1 抗体
AP2 associated kinase 1 (AAK1) 抗体AP2 associated kinase 1 (Aak1) 抗体
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