anti-LRP5 (LRP5) 抗体产品概述

Full name:
anti-Low Density Lipoprotein Receptor-Related Protein 5 抗体 (LRP5)
在www.antibodies-online.cn可供128 Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) 抗体的18不同的供货商。 再加上,我们可以发LRP5 试剂盒 (15)LRP5 蛋白 (10)和数多这个蛋白质的别的产品。 总共156 LRP5产品已列进来了。
BMND1, EVR1, EVR4, HBM, LR3, LRP5, lrp5-A, LRP6, LRP7, mKIAA4142, OPPG, OPS, OPTA1, VBCH2, Xlrp5

最受欢迎的抗anti-LRP5 (LRP5) 抗体


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抗Mouse (Murine) LRP5 抗体:

抗Rat (Rattus) LRP5 抗体:

所有可销售的anti-LRP5 抗体


引用最多的anti-LRP5 抗体

  1. Human Polyclonal LRP5 Primary Antibody for EIA, WB - ABIN953209 : Abramowitz, Muntner, Coco, Southern, Lotwin, Hostetter, Melamed: Serum alkaline phosphatase and phosphate and risk of mortality and hospitalization. in Clinical journal of the American Society of Nephrology : CJASN 2010 (PubMed)
    Show all 4 references for 953209

  2. Human Polyclonal LRP5 Primary Antibody for WB - ABIN127323 : Del Valle-Pérez, Arqués, Vinyoles, de Herreros, Duñach: Coordinated action of CK1 isoforms in canonical Wnt signaling. in Molecular and cellular biology 2011 (PubMed)
    Show all 2 references for 127323

  3. Human Polyclonal LRP5 Primary Antibody for IHC, ELISA - ABIN185410 : He, Semenov, Tamai, Zeng: LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. in Development (Cambridge, England) 2004 (PubMed)
    Show all 2 references for 185410

  4. Human Monoclonal LRP5 Primary Antibody for FACS, ELISA - ABIN969535 : Urano, Shiraki, Usui, Sasaki, Ouchi, Inoue: A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women. in Endocrine journal 2009 (PubMed)
    Show all 2 references for 969535

  5. Human Monoclonal LRP5 Primary Antibody for ELISA, WB - ABIN517568 : Kim, Goel, Alexander: Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept. in PLoS ONE 2011 (PubMed)


Xenopus laevis Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. The extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt (显示 WNT2 抗体) signaling during Xenopus and mouse development in vivo.

Zebrafish Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. Data show that in zebrafish, lrp5 also controls cell migration during early morphogenetic processes and contributes to shaping the craniofacial skeleton.

Human Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. VAP1 cleaved the extracellular region of LRP5. This cle (显示 AOC3 抗体)avage removes four inhibitory beta-propeller structures, resulting in activation of LRP5/6.

  2. Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (显示 NDP 抗体) (3/31, 9.7%), FZD4 (显示 FZD4 抗体) (2/31, 6.5%), TSPAN12 (显示 TSPAN12 抗体) (1/31, 3.2%), and KIF11 (显示 KIF11 抗体) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  3. wild-type and all five mutant LRP5 proteins were assayed for the ability to activate the Norrin (显示 NDP 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway by established luciferase reporter assays, and all mutants failed to activate the pathway.

  4. findings revealed an unrecognized role of Caprin-2 (显示 CAPRIN2 抗体) in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (显示 CDK14 抗体), Cyclin Y (显示 CCNY 抗体), and LRP5/6.

  5. This study did not identify LRP5 polymorphisms as a risk factor for osteoporosis in Thai menopausal women.

  6. We identified four novel LRP5 missense mutations in these FEVR (显示 NDP 抗体) families: c.C1042T (p.R348W), c.G1141A (p.D381N), c.C1870T (p.R624W), and c.A4550G (p.Y1517C). All four of these LRP5 mutations led to significant reduction of enzymatic activity with response to NORRIN (显示 NDP 抗体). Our findings expand the mutational spectrum of FEVR (显示 NDP 抗体) in the Indian population and provide some guidelines in clinical diagnosis.

  7. In this study, the splice site mutation c.2827thorn1G > A found in LRP5 (603506) gene is thought to cause microphthalmia in this family.

  8. A genetic evaluation of the known genes associated with familial exudative vitreoretinopathy (FEVR (显示 NDP 抗体)) revealed a novel variant in the LRP5 gene that co-segregated with the phenotype in the family.

  9. Meta-analysis indicates that the LRP5 Ala1330Val polymorphism may not be correlated with fracture susceptibility.

  10. Independently or combined with APOE (显示 APOE 抗体), LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. A mouse LRP5 ectodomain recombinant was cleaved by VAP1 (显示 AOC3 抗体), creating a peptide, VAHLTGIHAVEE, detected by mass spectrometric analysis of the 140-kDa fragment, suggesting that the sessile bond by VAP1 (显示 AOC3 抗体) is Glu1206-Val1207.

  2. we revealed miR (显示 MLXIP 抗体)-375-3p negatively regulated osteogenesis by targeting LRP5 and beta-catenin (显示 CTNNB1 抗体)

  3. lung myeloid cells are responsive to Lrp5/beta-catenin (显示 CTNNB1 抗体) signaling, leading to differentiation of an alveolar macrophage subtype that antagonizes the resolution of lung fibrosis.

  4. LRP5 is a novel anti-inflammatory macrophage marker that positively regulates migration, phagocytosis, lipid uptake and metabolism.

  5. These results revealed a new role of the canonical Lrp5/6-beta-catenin (显示 CTNNB1 抗体) pathway in regulating the morphogenesis of the cerebellum during postnatal development.

  6. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels.

  7. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture.

  8. Data show that LDL receptor (显示 LDLR 抗体)-related protein 5 (显示 CAPS 抗体) (LRP5) gain-of-function mutations do not activate beta-catenin (显示 CTNNB1 抗体) signaling in osteoblasts.

  9. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST (显示 SOST 抗体) and DKK1 (显示 DKK1 抗体).

  10. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models.

LRP5 抗原简介

Antigen Summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Alternative names and synonyms associated with LRP5

  • low density lipoprotein receptor-related protein 5 (LRP5) 抗体
  • low density lipoprotein receptor-related protein 5 (lrp5) 抗体
  • low density lipoprotein receptor-related protein 5 (LOC100220027) 抗体
  • low density lipoprotein receptor-related protein 5 (Lrp5) 抗体
  • BMND1 抗体
  • EVR1 抗体
  • EVR4 抗体
  • HBM 抗体
  • LR3 抗体
  • LRP5 抗体
  • lrp5-A 抗体
  • LRP6 抗体
  • LRP7 抗体
  • mKIAA4142 抗体
  • OPPG 抗体
  • OPS 抗体
  • OPTA1 抗体
  • VBCH2 抗体
  • Xlrp5 抗体

Protein level used designations for LRP5

Lipoprotein Receptor Related Protein 5 , low density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5-like , LRP-5 , low density lipoprotein receptor-related protein 7 , LRP-7 , low-density lipoprotein receptor-related protein 7

100147353 Equus caballus
100009566 Oryctolagus cuniculus
373722 Xenopus laevis
451380 Pan troglodytes
568518 Danio rerio
100189542 Papio anubis
100220027 Taeniopygia guttata
100406268 Callithrix jacchus
100473379 Ailuropoda melanoleuca
100491803 Xenopus (Silurana) tropicalis
100548748 Meleagris gallopavo
4041 Homo sapiens
16973 Mus musculus
293649 Rattus norvegicus
423114 Gallus gallus
100306933 Canis lupus familiaris
534450 Bos taurus
100524299 Sus scrofa
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