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Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin (显示 INS 蛋白) secretion. These effects were associated with an increase in the cellular content of JunB (显示 JUNB 蛋白), a potent inhibitor of ER stress and apoptosis.
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 (显示 C7orf27 蛋白) into the nucleus.
In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1 (显示 DMRT1 蛋白), including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.
Ndfip1 negatively regulates RIG-I (显示 DDX58 蛋白)-dependent immune signaling by enhancing E3 ligase Smurf1 (显示 SMURF1 蛋白)-mediated MAVS (显示 MAVS 蛋白) degradation.
Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
PTEN/Akt (显示 AKT1 蛋白) and MAP kinase (显示 MAPK1 蛋白) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 (显示 NDFIP2 蛋白)
Ndfip1 is required for the exosomal secretion of Nedd4 family proteins
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1 (显示 DMRT1 蛋白).
Data indicate thar Janus kinase 1 (Jak1 (显示 JAK1 蛋白)) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2 (显示 NDFIP2 蛋白).
transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors, resulting in microencephaly.
It attenuates 6-OHDA-induced iron accumulation via regulating the degradation of DMT1 (显示 SLC11A2 蛋白).
The results of this study indicated that Ndfip1, through its Nedd4 effectors, is important for the development of dendrites and dendritic spines in the cortex
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7 (显示 UBE2L3 蛋白).
Genomic deletion of Ndfip1 abrogated nuclear trafficking of ubiquitinated Pten, even in the presence of Rab5 (显示 RAB5A 蛋白).
Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B.
Ndfip1 deficiency precipitated autoimmune pancreatic destruction and diabetes; however, this depended on a further accumulation of nontolerant anti-self T cells from strong stimulation by exogenous tolerogen
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.
Nedd4 WW binding protein 5
, Nedd4 family interacting protein 1
, Nedd4 WW domain-binding protein 5
, NEDD4 family-interacting protein 1
, breast cancer-associated protein SGA-1M
, putative MAPK-activating protein PM13
, putative NF-kappa-B-activating protein 164
, putative NFKB and MAPK-activating protein
, NEDD4 WW domain-binding protein 5
, Nedd4 WW-binding protein 5