This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
custom-made
FTH1
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
FTH1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: "Impact of TET2 deficiency on iron metabolism in erythroblasts." in: Experimental hematology, Vol. 49, pp. 56-67.e5, (2017) (PubMed).
Chou, Gatti, Fuller, Concannon, Wong, Chada, Davis, Salser: "Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro." in: Molecular and cellular biology, Vol. 6, Issue 2, pp. 566-73, (1987) (PubMed).
Boyd, Vecoli, Belcher, Jain, Drysdale: "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones." in: The Journal of biological chemistry, Vol. 260, Issue 21, pp. 11755-61, (1985) (PubMed).
Costanzo, Santoro, Colantuoni, Bensi, Raugei, Romano, Cortese: "Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family." in: The EMBO journal, Vol. 3, Issue 1, pp. 23-7, (1984) (PubMed).
Aliases for FTH1 蛋白
ferritin heavy chain 1 (FTH1) 蛋白 ferritin, heavy polypeptide 1 L homeolog (fth1.L) 蛋白 ferritin, heavy polypeptide 1 S homeolog (fth1.S) 蛋白 ferritin heavy polypeptide 1 (Fth1) 蛋白 ferritin heavy chain 1 (Fth1) 蛋白 ferritin, heavy polypeptide 1a (fth1a) 蛋白 ferritin (EAMY_RS19690) 蛋白 ferritin, heavy polypeptide 1 (fth1) 蛋白 tudor domain containing 9 (TDRD9) 蛋白 ferritin, heavy polypeptide 1 (FTH1) 蛋白 ferritin, heavy polypeptide 1 a (fth1a) 蛋白 apoferritin 蛋白 fb06g09 蛋白 ferritin 蛋白 FHC 蛋白 fhc 蛋白 FTH 蛋白 fth 蛋白 Fth 蛋白 fth1 蛋白 fth1b 蛋白 FTHL6 蛋白 fthl6 蛋白 ftn-2 蛋白 HFt 蛋白 hm:zeh1145 蛋白 MFH 蛋白 PIG15 蛋白 pig15 蛋白 PLIF 蛋白 plif 蛋白 wu:fb06g09 蛋白 wu:fq18c10 蛋白 zeh1145 蛋白