TANK-Binding Kinase 1 (TBK1) ELISA试剂盒产品概述

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TANK-Binding Kinase 1 ELISA试剂盒 (TBK1)
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1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548

TANK-Binding Kinase 1 (TBK1) ELISA试剂盒 by Reactivity

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适于 TANK-Binding Kinase 1 相互作用对的更多 ELISA 试剂盒

Zebrafish TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Fish IRF6 (显示 IRF6 ELISA试剂盒) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (显示 MYD88 ELISA试剂盒) and TBK1, suggesting that differences in the IRF6 (显示 IRF6 ELISA试剂盒) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (显示 IGFALS ELISA试剂盒)) with or without comorbid frontotemporal dementia.

  2. The occurrence of TBK1 mutations in FTD (显示 FTL ELISA试剂盒) and ALS (显示 IGFALS ELISA试剂盒) underlines the fact that FTD (显示 FTL ELISA试剂盒) and ALS (显示 IGFALS ELISA试剂盒) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.

  3. demonstrate a key role of TBK1/IKKepsilon (显示 IKBKE ELISA试剂盒) in the survival and proliferation of HTLV-1-transformed T cells

  4. Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1-IKKepsilon (显示 IKBKE ELISA试剂盒)-IRF3 (显示 IRF3 ELISA试剂盒) complex, resulting in reduction in IRF3 (显示 IRF3 ELISA试剂盒) phosphorylation and type I interferon (显示 IFNA ELISA试剂盒) production. (TANK = TRAF family member associated NFKB activator (显示 TANK ELISA试剂盒); TBK1 = TANK binding kinase 1; IKKepsilon (显示 IKBKE ELISA试剂盒) = inhibitor of nuclear factor kappa B kinase subunit epsilon (显示 IKBKE ELISA试剂盒); IRF3 (显示 IRF3 ELISA试剂盒) = interferon regulatory factor 3 (显示 IRF3 ELISA试剂盒))

  5. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon (显示 IKBKE ELISA试剂盒)) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.

  6. Here the authors show that recruitment of WIPI2 (显示 WIPI2 ELISA试剂盒), itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria.

  7. review of the role of TBK1 in the seemingly unrelated, yet allelic diseases amyotrophic lateral sclerosis (ALS (显示 IGFALS ELISA试剂盒)), frontotemporal dementia (FTD (显示 FTL ELISA试剂盒)), normal tension glaucoma (NTG (显示 OPA1 ELISA试剂盒)) and childhood herpes simplex encephalitis and discuss the role of TBK1 in neuroinflammatory diseases

  8. Enrichment of qualifying variants toward glaucoma was present in all genes except WDR36, in which controls harbored more variants, and TBK1, in which no qualifying variants were detected in cases or controls.

  9. Human herpesvirus 1 ICP27 interacted with TBK1 and STING in a manner that was dependent on TBK1 activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 pathway in human macrophages.

  10. Upon cytosolic DNA stimulation, STAT3 (显示 STAT3 ELISA试剂盒) Ser (显示 SIGLEC1 ELISA试剂盒)(754) is directly phosphorylated by TBK1 in a STING-dependent manner. Moreover, Ser (显示 SIGLEC1 ELISA试剂盒)(754) phosphorylation inhibits cytosolic DNA-induced STAT3 (显示 STAT3 ELISA试剂盒) transcriptional activity and selectively reduces STAT3 (显示 STAT3 ELISA试剂盒) target genes that are up-regulated in response to cytosolic DNA

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) interaction partners

  1. USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.

  2. The authors report that Raf kinase inhibitory protein (RKIP (显示 PEBP1 ELISA试剂盒)) is essential for TBK1 activation and type I interferon (显示 IFNA ELISA试剂盒) production triggered by viral infection.

  3. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (显示 FOSL1 ELISA试剂盒) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (显示 TRAF3 ELISA试剂盒)), TIR domain-containing adapter inducing IFN-beta (显示 IFNB1 ELISA试剂盒) (TRIF (显示 RNF138 ELISA试剂盒)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (显示 TRAF3 ELISA试剂盒) and TRIF (显示 RNF138 ELISA试剂盒).

  4. TBK1 complexes required for the phosphorylation of IRF3 (显示 IRF3 ELISA试剂盒) and the production of interferon-beta (显示 IFNB1 ELISA试剂盒) have been identified.

  5. this study reveals a previously unknown ICOS (显示 ICOS ELISA试剂盒)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells

  6. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  7. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (显示 RPS6KB1 ELISA试剂盒))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (显示 IRF3 ELISA试剂盒)).

  8. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

  9. TRIM27 (显示 RFP ELISA试剂盒) inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation.

  10. Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon (显示 IKBKE ELISA试剂盒) and TBK1 may contribute to the repression of energy expenditure during obesity.

TANK-Binding Kinase 1 (TBK1) 抗原简介

Antigen Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1) Elisa Kit
  • TANK-binding kinase 1 (TBK1) Elisa Kit
  • TANK-binding kinase 1 (LOC100358771) Elisa Kit
  • TANK-binding kinase 1 (Tbk1) Elisa Kit
  • 1200008B05Rik Elisa Kit
  • AI462036 Elisa Kit
  • AW048562 Elisa Kit
  • NAK Elisa Kit
  • T2K Elisa Kit
  • TBK1 Elisa Kit
  • wu:fk70c05 Elisa Kit
  • zgc:136548 Elisa Kit

Protein level used designations for TBK1

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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