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抗Human Aurora Kinase B 抗体:
抗Mouse (Murine) Aurora Kinase B 抗体:
抗Rat (Rattus) Aurora Kinase B 抗体:
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN151760
Adams, Eckley, Vagnarelli, Wheatley, Gerloff, Mackay, Svingen, Kaufmann, Earnshaw: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. in Chromosoma 2001
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Human Monoclonal Aurora Kinase B Primary Antibody for IF, WB - ABIN968357
Chen, Jin, Tahir, Zhang, Liu, Sarthy, McGonigal, Liu, Rosenberg, Ng: Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. in The Journal of biological chemistry 2002
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Human Monoclonal Aurora Kinase B Primary Antibody for IF, WB - ABIN968358
Lange, Rebollo, Herold, González: Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. in The EMBO journal 2002
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Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN152999
Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006
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Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN965626
Song, So, Cheng, Tang, Croft: Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. in Immunity 2005
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Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN1724660
Kapoor, Lavoie, Frappier: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. in Molecular and cellular biology 2005
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Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN408113
Togashi, Shirakawa, Orime, Kaji, Sakamoto, Tajima, Inoue, Nakamura, Tochino, Goshima, Shimomura, Terauchi: β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. in Endocrinology 2014
Human Polyclonal Aurora Kinase B Primary Antibody for WB - ABIN2441645
Bailey, Fields, Cheng, Lee, Wagenaar, Lagrois, Schmidt, Xia, Ma: WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. in The Journal of biological chemistry 2015
Human Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN129612
Mackay, Makise, Ullman: Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. in The Journal of cell biology 2010
Human Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN1043878
Wheatley, Henzing, Dodson, Khaled, Earnshaw: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. in The Journal of biological chemistry 2004
Aurora A (显示 AURKA 抗体) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo (显示 PLK1 抗体) by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B a (显示 CDK1 抗体)nd Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (显示 CDC37 抗体)/Hsp90 (显示 HSP90 抗体) complex for its stability.
INCENP (显示 INCENP 抗体) binds to the cohesion protector protein (显示 PRDX2 抗体) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Our findings suggested that AURKA (显示 AURKA 抗体) (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 (显示 SPAG5 抗体) protein (Astrin (显示 SPAG5 抗体))-SKAP (显示 KNSTRN 抗体) complex in the end-on conversion process.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Aurora B kinase interacts with and phosphorylates Sgo1 (显示 SGOL1 抗体). Aurora B-mediated phosphorylation of Sgo1 (显示 SGOL1 抗体) regulates the distribution of Sgo1 (显示 SGOL1 抗体) between centromeres and chromosome arms.
AURKC (显示 AURKC 抗体) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA (显示 AURKA 抗体) rs1047972 and AURKC (显示 AURKC 抗体) rs758099 polymorphisms could affect the risk of GC development.
Aurora-C (显示 AURKC 抗体) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (显示 BIRC5 抗体) and Inner Centromere Protein (INCENP (显示 INCENP 抗体)) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C (显示 AURKC 抗体) overexpression in human cancer cells, is reported.
Aurora kinase (显示 AURKA 抗体) inhibitor danusertib negatively regulated AURKB/p70S6K (显示 RPS6KB1 抗体)/RPL15 (显示 RPL15 抗体) axis with the involvement of PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体), AMPK (显示 PRKAA1 抗体), and p38 MAPK (显示 MAPK14 抗体) signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
The kinase activity of Aurora B on serine 31 of histone H3.3 (显示 H3F3A 抗体) was biochemically confirmed with nucleosomal substrates in vitro.
in addition to its role in checkpoint signaling, MAD2 (显示 MAD2L1 抗体) ensures chromosome stability through the regulation of AURORA B.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (显示 AURKC 抗体) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (显示 AURKA 抗体) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (显示 POU5F1 抗体)(S229) during G2/M phase, leading to the dissociation of Oct4 (显示 POU5F1 抗体) from chromatin, whereas PP1 (显示 PPP1CC 抗体) binds Oct4 (显示 POU5F1 抗体) and dephosphorylates Oct4 (显示 POU5F1 抗体)(S229) during M/G1 transition, which resets Oct4 (显示 POU5F1 抗体)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (显示 AURKC 抗体) also results in a reduced DNA damage response and decreased levels of the p53 (显示 TP53 抗体) target p21(Cip1 (显示 CDKN1A 抗体)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF (显示 CDKN2A 抗体) as well as regulation of Aurora B (显示 AURKC 抗体) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (显示 AURKC 抗体) at the inner centromere region in cells lacking Pds5B (显示 PDS5B 抗体) impairs its error correction function, promoting chromosome mis (显示 AMH 抗体)-segregation and aneuploidy
Aurora B (显示 AURKC 抗体) and Ring1B (显示 RNF2 抗体) co-occupy active promoters in resting lymphocytes.
FBXL2 (显示 FBXL2 抗体) mediates Aurora B (显示 AURKC 抗体) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Inhibitions of Aurora B (显示 AURKC 抗体) and Cyclin-dependent kinase 1 (显示 CDK1 抗体) activity in vertebrate cells also have opposite effects on the timing of abscission.
Aurora B (显示 AURKC 抗体) represses p21(Cip1 (显示 CDKN1A 抗体)), preventing delayed DNA replication, Cdk (显示 CDK4 抗体) inhibition and premature mitotic exit.
Alterations in PGRMC1 (显示 PGRMC1 抗体) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora B
, aurora B kinase
, dAurora B
, aurora/IPL1-related kinase 2
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase aurora-B
, aurora kinase B
, serine/threonine-protein kinase 12-like
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 5
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of nuclear factor kappa-B kinase subunit beta
, nuclear factor NF-kappa-B inhibitor kinase beta