Use your antibodies-online credentials, if available.
Select your species
Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A (显示 VEGFA ELISA试剂盒) recapitulates the observed abnormalities
Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (显示 ARSD ELISA试剂盒)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (显示 ARSD ELISA试剂盒)
the expression of NL1 and its binding partner neurexin (显示 NRXN1 ELISA试剂盒)-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats.
Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation.
NLGN1 was associated with schizophrenia in Chinese Han Populations
Increasing expression of TGF-beta1 (显示 TGFB1 ELISA试剂盒) protein, decreasing expressions of Ghrelin (显示 GHRL ELISA试剂盒), Neurexin (显示 NRXN1 ELISA试剂盒), and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
Neuroligin-1 and Glu (显示 DCTN1 ELISA试剂盒) may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease.
Results indicate that the neurexin (显示 NRXN1 ELISA试剂盒) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 (显示 DISC1 ELISA试剂盒) function, thus contributing to a better understanding of the pathology of schizophrenia.
Monitoring the attachment and detachment of neurexin (Nrx (显示 NRXN1 ELISA试剂盒))-coated quantum dots measures the rates of neurexin (Nrx (显示 NRXN1 ELISA试剂盒))/neuroligin interaction in the hippocampus.
We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes
Co-expression of gamma-Pcdhs inhibits the ability of Nlg1 to increase spine density and to induce presynaptic differentiation in hippocampal neurons in vitro.
The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (显示 GUSB ELISA试剂盒)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (显示 GUSB ELISA试剂盒)
The results indicate that Nrx2alpha and NL1 (显示 MMEL1 ELISA试剂盒) are targets of Abeta (显示 APP ELISA试剂盒) oligomers and that prevention of this interaction reduces the deleterious impact of Abeta (显示 APP ELISA试剂盒) oligomers on synapses and cognition.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.
Results are indicative of an altered immediate response of the brain to peripheral stimulation in Nlgn1 KO mice, and suggest a role for NLGN1 in the regulation of cerebrovascular responses
the R451C mutation in the Nlgn3 (显示 NLGN3 ELISA试剂盒) gene, associated with autism spectrum disorder in humans, confers resistance to induced seizures
This study provided first evidence that NL1 (显示 MMEL1 ELISA试剂盒) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals.
NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin (显示 CDH5 ELISA试剂盒), laminin and alpha6 integrin distribution in vessels
transmembrane ligand for neurexins\; involved in development and maturation of synaptic connections
, neuroligin I
, neuroligin 1 isoform A1A2B