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Data show that interplay of Smad1/5 and MAP kinase (显示 MAPK1 ELISA试剂盒) signaling system (ERK (显示 MAPK1 ELISA试剂盒) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (显示 SMAD9 ELISA试剂盒) act redundantly to each other downstream of smad5 (显示 SMAD5 ELISA试剂盒) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (显示 SMAD5 ELISA试剂盒).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 retrotransposon contains the MAD protein (显示 MXD1 ELISA试剂盒) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (显示 GRIN2A ELISA试剂盒) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (显示 TGFb ELISA试剂盒) and Wnt (显示 WNT4 ELISA试剂盒) pathways depending on its phosphorylation state.
Yorkie (显示 YAP1 ELISA试剂盒) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (显示 TGFb ELISA试剂盒) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (显示 SRC ELISA试剂盒) and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) inhibitors or by the knockdown of Smad1 (显示 GARS ELISA试剂盒).
Low doses of IL1B (显示 IL1B ELISA试剂盒) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (显示 IL1B ELISA试剂盒) inhibit BMP/Smad signaling through the activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) and MAPK (显示 MAPK1 ELISA试剂盒) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (显示 GARS ELISA试剂盒) signaling pathway and inhibits Col (显示 HDAC1 ELISA试剂盒) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (显示 SMAD7 ELISA试剂盒) and both zeta-chain-associated protein kinase (显示 CDK7 ELISA试剂盒) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (显示 SMAD2 ELISA试剂盒)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (显示 GARS ELISA试剂盒)/8 and lower SMAD-4 (显示 SMAD4 ELISA试剂盒) expression in chronic lymphocytic leukemia cells
melatonin treatment was found to downregulate TNFalpha (显示 TNF ELISA试剂盒)-induced SMURF1 (显示 SMURF1 ELISA试剂盒) expression and then decrease SMURF1 (显示 SMURF1 ELISA试剂盒)-mediated ubiquitination and degradation of SMAD1 (显示 GARS ELISA试剂盒) protein
The expression of specific targets Smad1 (显示 GARS ELISA试剂盒) and Osterix (显示 SP7 ELISA试剂盒) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (显示 MUC7 ELISA试剂盒)+). As miR (显示 MLXIP ELISA试剂盒)-30b, miR (显示 MLXIP ELISA试剂盒)-133a, and miR (显示 MLXIP ELISA试剂盒)-143 are negatively regulated by Pi and restored by Mg(2 (显示 MUC7 ELISA试剂盒)+) with a congruent modulation of their known targets Runx2 (显示 RUNX2 ELISA试剂盒), Smad1 (显示 GARS ELISA试剂盒), and Osterix (显示 SP7 ELISA试剂盒), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
the BMP-2 (显示 BMP2 ELISA试剂盒)/Smad1 (显示 GARS ELISA试剂盒)/5/RUNX2 (显示 RUNX2 ELISA试剂盒) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (显示 BGLAP ELISA试剂盒) synth
Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (显示 GARS ELISA试剂盒).
The expression SMAD1 (显示 GARS ELISA试剂盒) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).
Overexpression of Smad1 (显示 GARS ELISA试剂盒) is associated with prostate cancer.
We discovered that Smad1/5/4-Amhr2 (显示 AMHR2 ELISA试剂盒)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (显示 AMHR2 ELISA试剂盒)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (显示 TGFB1 ELISA试剂盒)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (显示 YAP1 ELISA试剂盒) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (显示 BMP2 ELISA试剂盒)-YAP (显示 YAP1 ELISA试剂盒)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
Dynamin (显示 DNM1 ELISA试剂盒)-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2 (显示 BMP2 ELISA试剂盒)) and its receptors is dispensable for the initiation of Smad signaling
Thyroid-specific Smad1 and Smad5 (显示 SMAD5 ELISA试剂盒) double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 and Smad5 (显示 SMAD5 ELISA试剂盒) have overlapping functions to govern hepcidin (显示 HAMP ELISA试剂盒) transcription. Moreover, erythropoietin (显示 EPO ELISA试剂盒) and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin (显示 HAMP ELISA试剂盒) expression.
Actin cytoskeleton depolymerization inhibites BMP2 (显示 BMP2 ELISA试剂盒) signaling via blocking of Smad by dephosphorylated CNN1 (显示 CNN1 ELISA试剂盒) in osteoblast cells under simulated microgravity.
Store operated calcium entry negatively regulates the Smad1 signaling pathway and inhibits Col (显示 HDAC1 ELISA试剂盒) IV protein production in glomerular mesangial cells.
Thus, our findings identify an unrecognized function of neogenin (显示 NEO1 ELISA试剂盒) in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2 (显示 BMP2 ELISA试剂盒)-neogenin (显示 NEO1 ELISA试剂盒)-YAP (显示 YAP1 ELISA试剂盒)-Smad1, underlying astrogliogenesis in developing mouse neocortex.
Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta (显示 TGFB1 ELISA试剂盒)-SMAD signaling pathway.
interactions between miR (显示 MYLIP ELISA试剂盒)-26 and the Smad1 3'UTR (显示 UTS2R ELISA试剂盒) modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (显示 TGFB1 ELISA试剂盒) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (显示 SMAD2 ELISA试剂盒)/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 ELISA试剂盒).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1